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Literature summary extracted from

  • Jagadeesh, S.; Padma, T.; Parimala, H.; Chandramouli, K.H.; DSouza, C.J.; Thimmaiah, K.N.
    Inhibition of calmodulin-dependent cyclic AMP phosphodiesterase by phenoxazines (2006), Biochem. Biophys. Res. Commun., 342, 690-701.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.53 Calmodulin required, Km value 0.000057 mM Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 10-(3-pyrrolidin-1-ylpropyl)-2-(trifluoromethyl)-10H-phenoxazine
-
 Bos taurus
3.1.4.53 10-(4'-N-morpholinobutyl)-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 10-(4'-N-morpholinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 10-(4'-N-piperidinobutyl)-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 10-(4'-N-piperidinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 10-(4'-N-pyrrolidinobutyl)-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine increase of Km value in presence of inhibitor Bos taurus
3.1.4.53 10-[3'-[(beta-hydroxyethyl)-piperazino]propyl]-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 10-[30-[(beta-hydroxy ethyl)-piperazino]propyl]-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 10-[4'-(N-diethylamino)-butyl]-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 10-[4'-(N-diethylamino)butyl]-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 10-[4'-[(beta-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine
-
 Bos taurus
3.1.4.53 10-[4'-[(beta-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Bos taurus
-
 calmodulin-dependent cAMP-phosphodiesterase, commercial product
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 brain
-
 Bos taurus
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.53 0.00018
-
 10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 0.00038
-
 10-[4'-[(beta-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine
-
 Bos taurus
3.1.4.53 0.00054
-
 10-(4'-N-piperidinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 0.00055
-
 10-[4'-[(beta-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 0.00058
-
 10-(4'-N-pyrrolidinobutyl)-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 0.0006
-
 10-[4'-(N-diethylamino)butyl]-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 0.0007
-
 10-(4'-N-piperidinobutyl)-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 0.0008
-
 10-(4'-N-morpholinobutyl)-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 0.00087
-
 10-[30-[(beta-hydroxy ethyl)-piperazino]propyl]-2-chlorophenoxazine
-
 Bos taurus
3.1.4.53 0.00097
-
 10-[3'-[(beta-hydroxyethyl)-piperazino]propyl]-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 0.001
-
 10-(3-pyrrolidin-1-ylpropyl)-2-(trifluoromethyl)-10H-phenoxazine pH 7.5, 30°C Bos taurus
3.1.4.53 0.00101
-
 10-(4'-N-morpholinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
3.1.4.53 0.00105
-
 10-[4'-(N-diethylamino)-butyl]-2-chlorophenoxazine
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.53 0.0023
-
-
 Bos taurus 10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine
3.1.4.53 0.0031
-
-
 Bos taurus 10-[4'-[(b-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine
3.1.4.53 0.0044
-
-
 Bos taurus 10-[4'-[(b-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine