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Literature summary extracted from

  • Muacevic-Katanec, D.; Bradamante, V.; Poljicanin, T.; Reiner, Z.; Babic, Z.; Simeon-Rudolf, V.; Katanec, D.
    Clinical study on the effect of simvastatin on paraoxonase activity (2007), Arzneimittelforschung, 57, 647-653.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.8.1 simvastatin used for treatment of hyperlipoproteinemia type IIa and IIb, simvastatin leads to lipid lowering of total and LDL cholesterol and an increase in PON1 activity in patients with both types of hyperlipoproteinemia, mechanism involving apolipoprotein A-I, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.8.1 lipid particle the enzyme is predominantly associated to high-density lipoprotein HDL Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.8.1 Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.8.1 additional information Homo sapiens the enzyme depends on high-density lipoprotein HDL as carrier and site of action, PON1 acts as an antioxidant preventing low-density lipoprotein peroxidation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.8.1 Homo sapiens
-
 hyperlipoproteinemia type IIa and IIb patients
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.8.1 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.8.1 additional information the enzyme depends on high-density lipoprotein HDL as carrier and site of action, PON1 acts as an antioxidant preventing low-density lipoprotein peroxidation, overview Homo sapiens ?
-
 ?
3.1.8.1 paraoxon + H2O
-
 Homo sapiens diethylphosphate + 4-nitrophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.8.1 paraoxonase
-
 Homo sapiens
3.1.8.1 PON1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.8.1 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.8.1 10.5
-
 assay at Homo sapiens