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Literature summary extracted from

  • De Palma, C.; Meacci, E.; Perrotta, C.; Bruni, P.; Clementi, E.
    Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors (2006), Arterioscler. Thromb. Vasc. Biol., 26, 99-105.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information downregulation of N-SMase2 by siRNA leads to inhibition of TNFalpha-induced activation of endothelial nitric oxide synthase in the sphingomyelin and ceramide metabolism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Homo sapiens neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors are essentially involved in endothelial nitric oxide synthase activation by tumor necrosis factor alpha, regulation of the pathway, overview ?
-
 ?
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 endothelial cell
-
 Homo sapiens
-
3.1.4.12 endothelium
-
 Homo sapiens
-
3.1.4.12 HeLa cell
-
 Homo sapiens
-
3.1.4.12 umbilical vein endothelial cell i.e. HUVEC Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors are essentially involved in endothelial nitric oxide synthase activation by tumor necrosis factor alpha, regulation of the pathway, overview Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 N-SMase2
-
 Homo sapiens
3.1.4.12 neutral sphingomyelinase 2
-
 Homo sapiens