BRENDA - Enzyme Database

Synthesis and evaluation of hydroquinone derivatives as inhibitors of isocitrate lyase

Yang, H.C.; Yu, J.; Oh, K.B.; Shin, D.S.; Cho, W.J.; Shin, J.; Kim, S.; Arch. Pharm. Res. 30, 955-961 (2007)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.3.1
(E)-2-(3-methylnon-2-enyl)benzene-1,4-diol
-
Candida albicans
4.1.3.1
(E)-2-(4-hydroxy-3-methylbut-2-enyl)benzene-1,4-diol
-
Candida albicans
4.1.3.1
(E)-2-(9-hydroxy-3-methylnon-2-enyl)benzene-1,4-diol
-
Candida albicans
4.1.3.1
2-(3-methylbut-2-enyl)benzene-1,4-diol
-
Candida albicans
4.1.3.1
2-allylbenzene-1,4-diol
-
Candida albicans
4.1.3.1
halisulfate 1
-
Candida albicans
4.1.3.1
halisulfate 5
-
Candida albicans
4.1.3.1
hydrohalisulfate 1
-
Candida albicans
4.1.3.1
Itaconate
-
Candida albicans
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.3.1
Candida albicans
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
677867
Candida albicans
succinate + glyoxylate
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
4.1.3.1
0.06
-
-
Candida albicans
Itaconate
4.1.3.1
0.28
-
-
Candida albicans
(E)-2-(9-hydroxy-3-methylnon-2-enyl)benzene-1,4-diol
4.1.3.1
0.29
-
-
Candida albicans
(E)-2-(4-hydroxy-3-methylbut-2-enyl)benzene-1,4-diol
4.1.3.1
0.4
-
-
Candida albicans
(E)-2-(3-methylnon-2-enyl)benzene-1,4-diol
4.1.3.1
0.61
-
-
Candida albicans
2-(3-methylbut-2-enyl)benzene-1,4-diol
4.1.3.1
1.02
-
-
Candida albicans
2-allylbenzene-1,4-diol
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
4.1.3.1
0.06
-
-
Candida albicans
Itaconate
4.1.3.1
0.28
-
-
Candida albicans
(E)-2-(9-hydroxy-3-methylnon-2-enyl)benzene-1,4-diol
4.1.3.1
0.29
-
-
Candida albicans
(E)-2-(4-hydroxy-3-methylbut-2-enyl)benzene-1,4-diol
4.1.3.1
0.4
-
-
Candida albicans
(E)-2-(3-methylnon-2-enyl)benzene-1,4-diol
4.1.3.1
0.61
-
-
Candida albicans
2-(3-methylbut-2-enyl)benzene-1,4-diol
4.1.3.1
1.02
-
-
Candida albicans
2-allylbenzene-1,4-diol
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.3.1
(E)-2-(3-methylnon-2-enyl)benzene-1,4-diol
-
Candida albicans
4.1.3.1
(E)-2-(4-hydroxy-3-methylbut-2-enyl)benzene-1,4-diol
-
Candida albicans
4.1.3.1
(E)-2-(9-hydroxy-3-methylnon-2-enyl)benzene-1,4-diol
-
Candida albicans
4.1.3.1
2-(3-methylbut-2-enyl)benzene-1,4-diol
-
Candida albicans
4.1.3.1
2-allylbenzene-1,4-diol
-
Candida albicans
4.1.3.1
halisulfate 1
-
Candida albicans
4.1.3.1
halisulfate 5
-
Candida albicans
4.1.3.1
hydrohalisulfate 1
-
Candida albicans
4.1.3.1
Itaconate
-
Candida albicans
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
677867
Candida albicans
succinate + glyoxylate
-
-
-
?