EC Number | Cloned (Comment) | Organism |
---|---|---|
5.5.1.8 | expression in Escherichia coli | Salvia officinalis |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
5.5.1.8 | additional information | the recombinant enzyme is similarly truncated at E50 to provide a pseudomature form devoid of the plastid transit peptide | Salvia officinalis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.5.1.8 | (3R)-homolinalyl diphosphate | i.e. 2,6-dimethyl-2-vinyl-5-heptenyl diphosphate | Salvia officinalis | |
5.5.1.8 | (3R,S)2-fluorolinalyl diphosphate | - |
Salvia officinalis | |
5.5.1.8 | (3S)-homolinalyl diphosphate | i.e. 2,6-dimethyl-2-vinyl-5-heptenyl diphosphate | Salvia officinalis | |
5.5.1.8 | 2-Fluorogeranyl diphosphate | - |
Salvia officinalis | |
5.5.1.8 | 3-aza-2,3-dihydrogeranyl diphosphate | competitive inhibition, the aza-analog of the substrate is bound anomalously, perhaps as a consequence of the positive charge, bond distortion, or hydrogen bonding resulting from the N for C substitution, binding strutcure, overview | Salvia officinalis | |
5.5.1.8 | linalyl diphosphate | competitive inhibition, the enantioselective synthase readily distinguishes between (3R)- and (3S)-homolinalyl diphosphates, both of which were more effective inhibitors than is 3-azageranyl diphosphate, the fluorinated analogues prove to be the most potent competitive inhibitors | Salvia officinalis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.5.1.8 | geranyl diphosphate | Salvia officinalis | - |
(+)-bornyl diphosphate | the enzyme is involved in monoterpenoid cyclase catalysis, mechanism of this coupled isomerization-cyclization reaction, modeling, overview | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.5.1.8 | Salvia officinalis | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
5.5.1.8 | recombinant enzyme from Escherichia coli | Salvia officinalis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.5.1.8 | geranyl diphosphate | - |
Salvia officinalis | (+)-bornyl diphosphate | the enzyme is involved in monoterpenoid cyclase catalysis, mechanism of this coupled isomerization-cyclization reaction, modeling, overview | ? | |
5.5.1.8 | geranyl diphosphate | bornyl diphosphate synthase is an unusual example of a monoterpene synthase, because the diphosphate leaving group of the geranyl substrate is recaptured in the final product | Salvia officinalis | (+)-bornyl diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.5.1.8 | (+)-bornyl diphosphate synthase | - |
Salvia officinalis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.5.1.8 | 0.006 | - |
2-Fluorogeranyl diphosphate | - |
Salvia officinalis | |
5.5.1.8 | 0.058 | - |
(3R,S)2-fluorolinalyl diphosphate | - |
Salvia officinalis | |
5.5.1.8 | 0.214 | - |
(3R)-homolinalyl diphosphate | - |
Salvia officinalis | |
5.5.1.8 | 1.2 | - |
(3S)-homolinalyl diphosphate | - |
Salvia officinalis |