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Literature summary extracted from
- Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism (2007), Arch. Biochem. Biophys., 459, 295-300.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | additional information | a transient decrease of the GSH/GSSG ratio temporarily activates nSMase-1, while diminishing total glutathione without altering signficantly the GSH/GSSG ratio does not affect nSMase-1 activity, permanent decreases of total glutathione and GSH/GSSG redox ratio produce a sustained activation of nSMase-1 activity, overview | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.4.12 | ectopic overexpression of nSMase-1 gene in HEK293 cells | Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.12 | sphingomyelin + H2O | Homo sapiens | ex vivo redox regulation of nSMase-1 activity in HEK293 cells through a redox GSH-dependent mechanism, overview | N-acylsphingosine + choline phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.12 | sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
| 3.1.4.12 | sphingomyelin + H2O | ex vivo redox regulation of nSMase-1 activity in HEK293 cells through a redox GSH-dependent mechanism, overview | Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.12 | neutral sphingomyelinase-1 | - |
Homo sapiens |
| 3.1.4.12 | nSMase-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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