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Literature summary extracted from

  • Lecaille, F.; Vandier, C.; Godat, E.; Herve-Grepinet, V.; Broemme, D.; Lalmanach, G.
    Modulation of hypotensive effects of kinins by cathepsin K (2007), Arch. Biochem. Biophys., 459, 129-136.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.38 DTT
-
 Homo sapiens
3.4.22.38 DTT
-
 Rattus norvegicus

Application

EC Number Application Comment Organism
3.4.22.38 medicine it is shown that cathepsin K acts as a potent kinin-degrading enzyme in bloodstream. Contrary to cathepsin L, cathepsin K attenuates kallikrein-induced decrease of rat blood pressure, and reduces the hypotensive effect of bradykinin in a dose-dependant manner Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.38 expressed in Pichia pastoris Homo sapiens
3.4.22.38 expressed in Pichia pastoris Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.38 Y67L/L205A this mutant fails to degrade bradykinin, indicating that Tyr67 and Leu205 are key active site residues for the kinin degrading activity of cathepsin Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.38 Homo sapiens
-
-
-
3.4.22.38 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.38 plasma
-
 Homo sapiens
-
3.4.22.38 plasma
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.38 bradykinin + H2O
-
 Homo sapiens bradykinin(1-4) + bradykinin(5-9)
-
 ?
3.4.22.38 bradykinin + H2O
-
 Rattus norvegicus bradykinin(1-4) + bradykinin(5-9)
-
 ?
3.4.22.38 desArg-bradykinin + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.38 desArg-bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.22.38 Lys-bradykinin + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.38 Lys-bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.22.38 o-aminobenzoyl-bradykinin-(3-NO2-Tyr) + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.38 cathepsin K
-
 Homo sapiens
3.4.22.38 cathepsin K
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.38 28
-
 assay at Homo sapiens
3.4.22.38 28
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.38 5.5
-
 assay at Homo sapiens
3.4.22.38 5.5
-
 assay at Rattus norvegicus