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Literature summary extracted from

  • Eulitz, D.; Mannherz, H.G.
    Inhibition of deoxyribonuclease I by actin is to protect cells from premature cell death (2007), Apoptosis, 12, 1511-1521.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.21.1 expression in MCF-7 cell Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.21.1 A144Y mutant with extremely reduced actin binding capacity. Induction of apoptosis or necrosis by staurosporine or oxidative stress results in faster chromatin fragmentation in mutant cells. Inclusion of actin under these conditions inhibits chromatin degradation in wild-type, but not in mutant Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.21.1 actin inhibition of enzyme by actin may serve as a self-protection mechanism against premature DNA degradtion during cell damage Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.1 Mus musculus P49183
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.21.1 kidney
-
 Mus musculus
-

Subunits

EC Number Subunits Comment Organism
3.1.21.1 More interaction of enzyme with actin and inhibition by actin. Inhibition may serve as a self-protection mechanism against premature DNA degradtion during cell damage Mus musculus