Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhang, A.Y.; Yi, F.; Jin, S.; Xia, M.; Chen, Q.Z.; Gulbins, E.; Li, P.L.
    Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells (2007), Antioxid. Redox Signal., 9, 817-828.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 Fas ligand activates sphingomyelinases, expecially acid SMase Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information acid sphingomyelinase, ASM, downregulation by specific siRNA leads to reduced FasL-induced lipid raft clustering and Fas aggregation on endothelial cell membrane Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 cell membrane
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Bos taurus acid sphingomyelinase redox amplification in mediating the formation of lipid raft redox signaling platforms in coronary arterial endothelial cells, overview ?
-
 ?
3.1.4.12 sphingomyelin + H2O Bos taurus acid sphingomyelinase is involved in ceramide signaling, which is important in the lipid raft clustering and formation of redox signaling platform in cell membranes, overview, reactive oxygen species derived from ASM/ceramide triggered lipid raft redox signaling platforms can feedback regulate the ASM activity, FasL-induced O2- may be involved in this regulatory mechanism, overview N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 endothelial cell coronary arterial endothelial cells Bos taurus
-
3.1.4.12 heart coronary arterial endothelial cells Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information acid sphingomyelinase redox amplification in mediating the formation of lipid raft redox signaling platforms in coronary arterial endothelial cells, overview Bos taurus ?
-
 ?
3.1.4.12 N-methyl-sphingomyelin + H2O
-
 Bos taurus N-methyl-N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Bos taurus N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O acid sphingomyelinase is involved in ceramide signaling, which is important in the lipid raft clustering and formation of redox signaling platform in cell membranes, overview, reactive oxygen species derived from ASM/ceramide triggered lipid raft redox signaling platforms can feedback regulate the ASM activity, FasL-induced O2- may be involved in this regulatory mechanism, overview Bos taurus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid SMase
-
 Bos taurus
3.1.4.12 acid sphingomyelinase
-
 Bos taurus
3.1.4.12 ASM
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 5
-
 ASM assay at Bos taurus