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Literature summary extracted from

  • Ferreira, R.R.; Meinhardt, L.W.; Azevedo, R.A.
    Lysine and threonine biosynthesis in sorghum seeds: characterisation of aspartate kinase and homoserine dehydrogenase isoenzymes (2006), Ann. Appl. Biol., 149, 77-86.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.2.4 L-lysine partially inhibits the first isoenzyme Sorghum bicolor
2.7.2.4 L-methionine inhibits the first isoenzyme at 5 mM Sorghum bicolor
2.7.2.4 L-threonine some inhibition of the first isoenzyme, together with L-lysine total inhibition Sorghum bicolor
2.7.2.4 additional information KCl, calcium, EGTA, calmodulin, compound 48/80 and L-valine have no effect on AK activity of the first isoenzyme Sorghum bicolor
2.7.2.4 S-2-aminoethyl-L-cysteine less effective on the first isoenzyme than L-lysine alone Sorghum bicolor
2.7.2.4 S-adenosyl-L-methionine only able to inhibit AK activity of the the first isoenzyme synergistically, when present with either L-lysine or L-threonine Sorghum bicolor

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.2.4 Mg2+
-
Sorghum bicolor

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.2.4 79000
-
second AK isoenzyme, gel filtration Sorghum bicolor
2.7.2.4 167000
-
first AK isoenzyme, gel filtration Sorghum bicolor

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.4 Sorghum bicolor
-
Massa 03
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.2.4 partially purified, 29.9fold, by gel filtration Sorghum bicolor

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.2.4 seed
-
Sorghum bicolor
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.4 ATP + L-aspartate
-
Sorghum bicolor ADP + 4-phospho-L-aspartate
-
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Synonyms

EC Number Synonyms Comment Organism
2.7.2.4 AK
-
Sorghum bicolor