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Literature summary extracted from

  • Tanaka, H.; Yamamoto, A.; Ishida, T.; Horiike, K.
    Simultaneous measurement of D-serine dehydratase and d-amino acid oxidase activities by the detection of 2-oxo-acid formation with reverse-phase high-performance liquid chromatography (2007), Anal. Biochem., 362, 83-88.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 benzoate potent competitive inhibitor Gallus gallus
1.4.3.3 benzoate potent competitive inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.18 D-serine Gallus gallus
-
 pyruvate + NH3
-
 ?
4.3.1.18 D-serine Rattus norvegicus
-
 pyruvate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Gallus gallus
-
-
-
1.4.3.3 Rattus norvegicus
-
-
-
4.3.1.18 Gallus gallus
-
-
-
4.3.1.18 Rattus norvegicus
-
 Sprague-Dawley male rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain
-
 Rattus norvegicus
-
1.4.3.3 kidney
-
 Gallus gallus
-
1.4.3.3 kidney
-
 Rattus norvegicus
-
1.4.3.3 liver
-
 Gallus gallus
-
1.4.3.3 liver
-
 Rattus norvegicus
-
1.4.3.3 additional information not detected in brain Gallus gallus
-
4.3.1.18 brain
-
 Gallus gallus
-
4.3.1.18 brain
-
 Rattus norvegicus
-
4.3.1.18 kidney
-
 Gallus gallus
-
4.3.1.18 kidney
-
 Rattus norvegicus
-
4.3.1.18 liver
-
 Gallus gallus
-
4.3.1.18 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.3 0.0004
-
 specific activity in liver, at 37°C Rattus norvegicus
1.4.3.3 0.00045
-
 specific activity in liver, at 37°C Gallus gallus
1.4.3.3 0.0007
-
 specific activity in brain, at 37°C Rattus norvegicus
1.4.3.3 0.014
-
 specific activity in kidney, at 37°C Gallus gallus
1.4.3.3 0.087
-
 specific activity in kidney, at 37°C Rattus norvegicus
4.3.1.18 additional information
-
 not detectable, activity of DSD in rats is compared to the activity of DSD in chicken Rattus norvegicus
4.3.1.18 0.0004
-
 liver Gallus gallus
4.3.1.18 0.0004
-
 brain Gallus gallus
4.3.1.18 0.0044
-
 kidney Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-serine + H2O + O2
-
 Gallus gallus 2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-serine + H2O + O2
-
 Rattus norvegicus 3-hydroxypyruvate + NH3 + H2O2
-
 ?
4.3.1.18 D-serine
-
 Gallus gallus pyruvate + NH3
-
 ?
4.3.1.18 D-serine
-
 Rattus norvegicus pyruvate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Gallus gallus
1.4.3.3 D-amino acid oxidase
-
 Rattus norvegicus
1.4.3.3 DAO
-
 Gallus gallus
1.4.3.3 DAO
-
 Rattus norvegicus
4.3.1.18 D-serine ammonia-lyase
-
 Gallus gallus
4.3.1.18 D-serine ammonia-lyase
-
 Rattus norvegicus
4.3.1.18 D-serine dehydratase
-
 Gallus gallus
4.3.1.18 D-serine dehydratase
-
 Rattus norvegicus
4.3.1.18 DSD
-
 Gallus gallus
4.3.1.18 DSD
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.3.1.18 37
-
 activity assay Gallus gallus
4.3.1.18 37
-
 activity assay Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.3.1.18 7.6
-
 activity assay Gallus gallus
4.3.1.18 7.6
-
 activity assay Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Gallus gallus
1.4.3.3 FAD
-
 Rattus norvegicus