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Literature summary extracted from
- Phospholipase A2 inhibition at different substrate concentrations (2006), Anal. Biochem., 359, 280-282.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.4 | aristolochic acid | - |
Sus scrofa |  |
| 3.1.1.4 | additional information | epigallocatechin is a poor inhibitor | Sus scrofa | |
| 3.1.1.4 | quercetin | - |
Sus scrofa | |
| 3.1.1.4 | quercetin-3-beta-D-glucoside | - |
Sus scrofa | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.4 | extracellular | secretory phospholipase A2 type IB | Sus scrofa | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.4 | Ca2+ | required | Sus scrofa | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.4 | Sus scrofa | P00592 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.4 | commercial preparation | from pancreas | Sus scrofa | - |
| 3.1.1.4 | pancreas | commercial preparation | Sus scrofa | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.4 | 1,2-dihexadecanoyl-rac-glycero-3-phosphorac-(1-glycerol) + H2O | pyrene-modified or unmodified phospholipid substrate | Sus scrofa | ? | - |
? | |
| 3.1.1.4 | 1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphogylcerol + H2O | - |
Sus scrofa | 1-hexadecanoyl-glycero-3-phosphoethanolamine + 1-pyrenedecanoate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.4 | secretory phospholipase A2 type IB | - |
Sus scrofa |
| 3.1.1.4 | sPLA2 IB | - |
Sus scrofa |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.4 | 37 | - |
assay at | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.4 | 7.4 | - |
assay at | Sus scrofa |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.1.4 | 0.01 | - |
pH 7.4, 37°C, isozyme sPLA2 IB | Sus scrofa | quercetin | |
| 3.1.1.4 | 0.01 | - |
pH 7.4, 37°C, isozyme sPLA2 IB | Sus scrofa | aristolochic acid | |
| 3.1.1.4 | 0.02 | - |
pH 7.4, 37°C, isozyme sPLA2 IB | Sus scrofa | quercetin-3-beta-D-glucoside | |
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