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Literature summary extracted from
- TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes (2007), Am. J. Physiol. Lung Cell Mol. Physiol., 292, L215-L222.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.4.1.20 | molecular biology | TNF-alpha exposure downregulates the LTC4 synthase gene expression in monocytes/macrophages via a transcriptional mechanism | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.20 | Tumor necrosis factor alpha | - |
Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.20 | Mus musculus | Q60860 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.4.1.20 | eosinophilic leukemia cell line | - |
Mus musculus | - |
| 4.4.1.20 | monocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.20 | leukotriene A4 + glutathione | - |
Mus musculus | leukotriene C4 | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.4.1.20 | leukotriene C4 synthetase | - |
Mus musculus |
| 4.4.1.20 | LTC4 synthase | - |
Mus musculus |
| 4.4.1.20 | LTC4S | - |
Mus musculus |
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Release 2023.1 (January 2023)
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