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Literature summary extracted from

  • Bastida, C.M.; Cremades, A.; Castells, M.T.; Lopez-Contreras, A.J.; Lopez-Garcia, C.; Sanchez-Mas, J.; Penafiel, R.
    Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels (2007), Am. J. Physiol. Endocrinol. Metab., 292, E1010-E1017.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.17 alpha-difluoromethylornithine a suicide inhibitor of ODC Mus musculus
4.1.1.17 testosterone 29% decrease in activity in female mice, more important chnage in female compared to male mice, overview Mus musculus
4.1.1.17 testosterone propionate decreases ODC activity by 56% in adrenal gland of castrated male mice, not in female mice Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.17 L-ornithine Mus musculus the enzyme is involved in polyamine biosynthesis, and is regulated mainly by posttranscriptional mechanisms, influence of polyamine deprivation on catecholamine and corticoid levels, sexual dimorphism of the enzyme in the adrenal gland resulting in sex-related differences in prevalent diseases and stress responses, overview putrescine + CO2
-
 ?
4.1.1.17 additional information Mus musculus circadian variations in ODC activity in female and male mice, influence of sex hormones, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Mus musculus P00860 ODC1; Swiss CD1 mice
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.17 adrenal gland sexual dimorphism of the enzyme in the adrenal Mus musculus
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4.1.1.17 additional information adrenal weight, ODC activity, immunoreactivity, and corticosterone and aldosterone secretion are higher in female than in male mice, while orchidectomy brings the male parameters closer to the values of females, overview Mus musculus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.17 additional information
-
 circadian variations in ODC activity in female and male mice, overview Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 L-ornithine
-
 Mus musculus putrescine + CO2
-
 ?
4.1.1.17 L-ornithine the enzyme is involved in polyamine biosynthesis, and is regulated mainly by posttranscriptional mechanisms, influence of polyamine deprivation on catecholamine and corticoid levels, sexual dimorphism of the enzyme in the adrenal gland resulting in sex-related differences in prevalent diseases and stress responses, overview Mus musculus putrescine + CO2
-
 ?
4.1.1.17 additional information circadian variations in ODC activity in female and male mice, influence of sex hormones, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.17 ODC
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.17 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.17 7.2
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.17 pyridoxal 5'-phosphate
-
 Mus musculus