BRENDA - Enzyme Database

Adenosine as a metabolic regulator of tissue function: production of adenosine by cytoplasmic 5'-nucleotidases

Borowiec, A.; Lechward, K.; Tkacz-Stachowska, K.; Skladanowski, A.C.; Acta Biochim. Pol. 53, 269-278 (2006)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.3.5
2,3-bisphosphoglycerate
-
Homo sapiens
3.1.3.5
ADP
; strongly activated by ADP
Homo sapiens
3.1.3.5
ATP
-
Homo sapiens
3.1.3.5
dATP
-
Homo sapiens
3.1.3.5
diadenosine 5',5'''-P1,P4-tetraphosphate
-
Homo sapiens
3.1.3.5
GTP
; activates
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.5
5'-deoxy-5'-S-isobutylthioadenosine
-
Homo sapiens
3.1.3.5
5-ethynyldideoxyuridine
selective inhibitor
Homo sapiens
3.1.3.5
6-Thiopurine
-
Homo sapiens
3.1.3.5
pentoxifillin
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.1.3.5
1.46
-
5'-AMP
partially purified enzyme isolated from heart
Homo sapiens
3.1.3.5
1.9
-
5'-AMP
recombinant enzyme from heart
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.5
cytoplasm
-
Homo sapiens
5737
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.5
Co2+
-
Homo sapiens
3.1.3.5
Mg2+
-
Homo sapiens
3.1.3.5
Mn2+
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.5
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.5
brain
-
Homo sapiens
-
3.1.3.5
erythrocyte
-
Homo sapiens
-
3.1.3.5
heart
-
Homo sapiens
-
3.1.3.5
kidney
-
Homo sapiens
-
3.1.3.5
lymphoid cell
-
Homo sapiens
-
3.1.3.5
pancreas
-
Homo sapiens
-
3.1.3.5
skeletal muscle
-
Homo sapiens
-
3.1.3.5
testis
-
Homo sapiens
-
3.1.3.5
uterus
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.5
5'-AMP + H2O
-
677295
Homo sapiens
adenosine + phosphate
-
-
-
?
3.1.3.5
5'-CMP + H2O
-
677295
Homo sapiens
cytidine + phosphate
-
-
-
?
3.1.3.5
5'-dCMP + H2O
-
677295
Homo sapiens
deoxycytidine + phosphate
-
-
-
?
3.1.3.5
5'-dCMP + H2O
-
677295
Homo sapiens
2'-deoxycytidine + phosphate
-
-
-
?
3.1.3.5
5'-dGMP + H2O
-
677295
Homo sapiens
deoxyguanosine + phosphate
-
-
-
?
3.1.3.5
5'-dIMP + H2O
-
677295
Homo sapiens
deoxyinosine + phosphate
-
-
-
?
3.1.3.5
5'-dTMP + H2O
-
677295
Homo sapiens
deoxythymidine + phosphate
-
-
-
?
3.1.3.5
5'-dUMP + H2O
-
677295
Homo sapiens
deoxyuridine + phosphate
-
-
-
?
3.1.3.5
5'-GMP + H2O
-
677295
Homo sapiens
guanosine + phosphate
-
-
-
?
3.1.3.5
5'-IMP + H2O
-
677295
Homo sapiens
inosine + phosphate
-
-
-
?
3.1.3.5
5'-UMP + H2O
-
677295
Homo sapiens
uridine + phosphate
-
-
-
?
3.1.3.5
5'-XMP + H2O
-
677295
Homo sapiens
xanthosine + phosphate
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.1.3.5
0.02
-
-
Homo sapiens
5-ethynyldideoxyuridine
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.3.5
2,3-bisphosphoglycerate
-
Homo sapiens
3.1.3.5
ADP
; strongly activated by ADP
Homo sapiens
3.1.3.5
ATP
-
Homo sapiens
3.1.3.5
dATP
-
Homo sapiens
3.1.3.5
diadenosine 5',5'''-P1,P4-tetraphosphate
-
Homo sapiens
3.1.3.5
GTP
; activates
Homo sapiens
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.1.3.5
0.02
-
-
Homo sapiens
5-ethynyldideoxyuridine
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.5
5'-deoxy-5'-S-isobutylthioadenosine
-
Homo sapiens
3.1.3.5
5-ethynyldideoxyuridine
selective inhibitor
Homo sapiens
3.1.3.5
6-Thiopurine
-
Homo sapiens
3.1.3.5
pentoxifillin
-
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.1.3.5
1.46
-
5'-AMP
partially purified enzyme isolated from heart
Homo sapiens
3.1.3.5
1.9
-
5'-AMP
recombinant enzyme from heart
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.5
cytoplasm
-
Homo sapiens
5737
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.5
Co2+
-
Homo sapiens
3.1.3.5
Mg2+
-
Homo sapiens
3.1.3.5
Mn2+
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.5
brain
-
Homo sapiens
-
3.1.3.5
erythrocyte
-
Homo sapiens
-
3.1.3.5
heart
-
Homo sapiens
-
3.1.3.5
kidney
-
Homo sapiens
-
3.1.3.5
lymphoid cell
-
Homo sapiens
-
3.1.3.5
pancreas
-
Homo sapiens
-
3.1.3.5
skeletal muscle
-
Homo sapiens
-
3.1.3.5
testis
-
Homo sapiens
-
3.1.3.5
uterus
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.5
5'-AMP + H2O
-
677295
Homo sapiens
adenosine + phosphate
-
-
-
?
3.1.3.5
5'-CMP + H2O
-
677295
Homo sapiens
cytidine + phosphate
-
-
-
?
3.1.3.5
5'-dCMP + H2O
-
677295
Homo sapiens
deoxycytidine + phosphate
-
-
-
?
3.1.3.5
5'-dCMP + H2O
-
677295
Homo sapiens
2'-deoxycytidine + phosphate
-
-
-
?
3.1.3.5
5'-dGMP + H2O
-
677295
Homo sapiens
deoxyguanosine + phosphate
-
-
-
?
3.1.3.5
5'-dIMP + H2O
-
677295
Homo sapiens
deoxyinosine + phosphate
-
-
-
?
3.1.3.5
5'-dTMP + H2O
-
677295
Homo sapiens
deoxythymidine + phosphate
-
-
-
?
3.1.3.5
5'-dUMP + H2O
-
677295
Homo sapiens
deoxyuridine + phosphate
-
-
-
?
3.1.3.5
5'-GMP + H2O
-
677295
Homo sapiens
guanosine + phosphate
-
-
-
?
3.1.3.5
5'-IMP + H2O
-
677295
Homo sapiens
inosine + phosphate
-
-
-
?
3.1.3.5
5'-UMP + H2O
-
677295
Homo sapiens
uridine + phosphate
-
-
-
?
3.1.3.5
5'-XMP + H2O
-
677295
Homo sapiens
xanthosine + phosphate
-
-
-
?