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Literature summary extracted from

  • Gutierrez, J.A.; Luo, M.; Singh, V.; Li, L.; Brown, R.L.; Norris, G.E.; Evans, G.B.; Furneaux, R.H.; Tyler, P.C.; Painter, G.F.; Lenz, D.H.; Schramm, V.L.
    Picomolar inhibitors as transition-state probes of 5-methylthioadenosine nucleosidases (2007), ACS Chem. Biol., 2, 725-734.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.16 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme Escherichia coli
3.2.2.16 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Helicobacter pylori
3.2.2.16 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Neisseria meningitidis
3.2.2.16 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme Staphylococcus aureus
3.2.2.16 4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme Streptococcus pneumoniae
3.2.2.16 benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme Escherichia coli
3.2.2.16 benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Helicobacter pylori
3.2.2.16 benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Neisseria meningitidis
3.2.2.16 benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme Staphylococcus aureus
3.2.2.16 benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme Streptococcus pneumoniae
3.2.2.16 ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme Escherichia coli
3.2.2.16 ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Helicobacter pylori
3.2.2.16 ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Neisseria meningitidis
3.2.2.16 ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme Staphylococcus aureus
3.2.2.16 ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme Streptococcus pneumoniae
3.2.2.16 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme Escherichia coli
3.2.2.16 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Helicobacter pylori
3.2.2.16 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Neisseria meningitidis
3.2.2.16 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme Staphylococcus aureus
3.2.2.16 methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.16 Escherichia coli
-
-
-
3.2.2.16 Helicobacter pylori
-
-
-
3.2.2.16 Neisseria meningitidis
-
-
-
3.2.2.16 Staphylococcus aureus
-
-
-
3.2.2.16 Streptococcus pneumoniae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.2.2.16 S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine early dissociative transition state Staphylococcus aureus
3.2.2.16 S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine early dissociative transition state Neisseria meningitidis
3.2.2.16 S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine early dissociative transition state Helicobacter pylori
3.2.2.16 S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine late dissociative transition state Escherichia coli
3.2.2.16 S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine late dissociative transition state Streptococcus pneumoniae