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Literature summary extracted from

  • Ellis, E.C.
    Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes (2006), World J. Gastroenterol., 12, 4640-4645.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.139 additional information thyroid hormone triiodothyronine, i.e. T3, supresses enzyme expression in vivo Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.139 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens thyroid hormone triiodothyronine has a regulatory function on the enzyme expressiona and bile acid metabolism, overview 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.139 hepatocyte primary Homo sapiens
-
1.14.14.139 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 thyroid hormone triiodothyronine has a regulatory function on the enzyme expressiona and bile acid metabolism, overview Homo sapiens 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?