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Literature summary extracted from

  • Balla, A.; Balla, T.
    Phosphatidylinositol 4-kinases: old enzymes with emerging functions (2006), Trends Cell Biol., 16, 351-361.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.67 Triton X-100
-
 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 adenosine inhibits in the millimolar range Saccharomyces cerevisiae
2.7.1.67 Ca2+
-
 Saccharomyces cerevisiae
2.7.1.67 Ly-294002 IC50: 0.05-0.1 mM; IC50: 0.1 mM Saccharomyces cerevisiae
2.7.1.67 additional information insensitive to wortmannin and LY-294002 Saccharomyces cerevisiae
2.7.1.67 Phenylarsine oxide IC50: 0.001-0.005 mM; IC50: 0.03 mM; IC50: above 0.1 mM Saccharomyces cerevisiae
2.7.1.67 Wortmannin IC50: 0.05-0.3 mM; IC50: 50-300 nM Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.67 0.01 0.05 ATP
-
 Saccharomyces cerevisiae
2.7.1.67 0.02 0.06 1-phosphatidyl-1D-myo-inositol
-
 Saccharomyces cerevisiae
2.7.1.67 0.1
-
 1-phosphatidyl-1D-myo-inositol
-
 Saccharomyces cerevisiae
2.7.1.67 0.4
-
 ATP
-
 Saccharomyces cerevisiae
2.7.1.67 0.7
-
 ATP
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 Golgi apparatus
-
 Saccharomyces cerevisiae 5794
-
2.7.1.67 plasma membrane
-
 Saccharomyces cerevisiae 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 additional information no direct effect by Ca2+ Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.67 54000
-
 calculated from amino acid sequence Saccharomyces cerevisiae
2.7.1.67 55000
-
 calculated from amino acid sequence Saccharomyces cerevisiae
2.7.1.67 92000
-
 calculated from amino acid sequence Saccharomyces cerevisiae
2.7.1.67 230000
-
 calculated from amino acid sequence Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 56 kDa type II PtdIns 4-kinase
-
 Saccharomyces cerevisiae
2.7.1.67 Lsb6p
-
 Saccharomyces cerevisiae
2.7.1.67 phosphatidylinositol 4-kinase
-
 Saccharomyces cerevisiae
2.7.1.67 Pik1p
-
 Saccharomyces cerevisiae
2.7.1.67 PIK230
-
 Saccharomyces cerevisiae
2.7.1.67 Pik2p
-
 Saccharomyces cerevisiae
2.7.1.67 Pik4ca
-
 Saccharomyces cerevisiae
2.7.1.67 PIK4IIalpha
-
 Saccharomyces cerevisiae
2.7.1.67 PIK4IIbeta
-
 Saccharomyces cerevisiae
2.7.1.67 PIK4IIIalpha
-
 Saccharomyces cerevisiae
2.7.1.67 PIK4IIIbeta
-
 Saccharomyces cerevisiae
2.7.1.67 PIK55
-
 Saccharomyces cerevisiae
2.7.1.67 PtdIns 4-kinase
-
 Saccharomyces cerevisiae
2.7.1.67 PtdIns 4-kinase beta
-
 Saccharomyces cerevisiae
2.7.1.67 Stt4p
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.67 ATP
-
 Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.67 0.01 0.07 adenosine
-
 Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.67 0.00005 0.0003 IC50: 50-300 nM Saccharomyces cerevisiae Wortmannin
2.7.1.67 0.001 0.005 IC50: 0.001-0.005 mM Saccharomyces cerevisiae Phenylarsine oxide
2.7.1.67 0.03
-
 IC50: 0.03 mM Saccharomyces cerevisiae Phenylarsine oxide
2.7.1.67 0.05 0.1 IC50: 0.05-0.1 mM Saccharomyces cerevisiae Ly-294002
2.7.1.67 0.05 0.3 IC50: 0.05-0.3 mM Saccharomyces cerevisiae Wortmannin
2.7.1.67 0.1
-
 IC50: 0.1 mM Saccharomyces cerevisiae Ly-294002
2.7.1.67 0.1
-
 IC50: above 0.1 mM Saccharomyces cerevisiae Phenylarsine oxide