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Literature summary extracted from
- Glutathione peroxidase and glutathione reductase activities are partially responsible for determining the susceptibility of cells to oxidative stress (2006), Toxicology, 226, 126-130.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.11.1.9 | analysis | activity is important in predicting tissue redox state | Mus musculus |
| 1.11.1.9 | analysis | activity is important in predicting tissue redox state | Homo sapiens |
| 1.11.1.9 | analysis | activity is important in predicting tissue redox state | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | Homo sapiens | - |
- |
- |
| 1.8.1.7 | Rattus norvegicus | - |
- |
- |
| 1.11.1.9 | Homo sapiens | - |
- |
- |
| 1.11.1.9 | Mus musculus | - |
- |
- |
| 1.11.1.9 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | C6 glioma cell | - |
Rattus norvegicus | - |
| 1.8.1.7 | Hep-G2 cell | - |
Homo sapiens | - |
| 1.11.1.9 | brain | activity in brain is much lower than in liver | Mus musculus | - |
| 1.11.1.9 | C6 glioma cell | - |
Rattus norvegicus | - |
| 1.11.1.9 | cerebellum | - |
Mus musculus | - |
| 1.11.1.9 | Hep-G2 cell | - |
Homo sapiens | - |
| 1.11.1.9 | hippocampus | - |
Mus musculus | - |
| 1.11.1.9 | liver | activity in brain is much lower than in liver | Mus musculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 1.07 | - |
in C6 glioma cells, pH and temperature not specified in the publication | Rattus norvegicus |
| 1.8.1.7 | 5.63 | - |
in HepG2 cells, pH and temperature not specified in the publication | Homo sapiens |
| 1.11.1.9 | 2.24 | - |
- |
Homo sapiens |
| 1.11.1.9 | 2.24 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | glutathione disulfide + NADPH + H+ | - |
Homo sapiens | glutathione + NADP+ | - |
? |  |
| 1.8.1.7 | glutathione disulfide + NADPH + H+ | - |
Rattus norvegicus | glutathione + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | glutathione reductase | - |
Homo sapiens |
| 1.8.1.7 | glutathione reductase | - |
Rattus norvegicus |
| 1.8.1.7 | GR | - |
Homo sapiens |
| 1.8.1.7 | GR | - |
Rattus norvegicus |
| 1.11.1.9 | GPX | - |
Mus musculus |
| 1.11.1.9 | GPX | - |
Homo sapiens |
| 1.11.1.9 | GPX | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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