Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gregus, Z.; Nemeti, B.
    The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol (2005), Toxicol. Sci., 85, 859-869.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.20.4.1 ADP moderate Homo sapiens
1.20.4.1 ADP moderate Rattus norvegicus
1.20.4.1 ATP moderate Homo sapiens
1.20.4.1 ATP moderate Rattus norvegicus
1.20.4.1 Koningic acid inhibition of both classical enzymic and arsentate reductase activities of glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
1.20.4.1 Koningic acid inhibition of both classical enzymic and arsentate reductase activities of glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus
1.20.4.1 NADH strong Homo sapiens
1.20.4.1 NADH strong Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.20.4.1 cytosol besides glyceraldehyde-3-phosphate dehydrogenase, presence of other enzymes contributing to arsenate reduction Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.20.4.1 Homo sapiens
-
 glyceraldehyde-3-phosphate dehydrogenase working as arsenate reductase
-
1.20.4.1 Rattus norvegicus
-
 glyceraldehyde-3-phosphate dehydrogenase working as arsenate reductase
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.20.4.1 arsenate + glutathione + glutaredoxin = arsenite + a glutaredoxin-glutathione disulfide + H2O arsenate reduction by glyceraldehyde-3-phosphate dehydrogenase may take place during or as a consequence of, the arsenolytic cleavage of the thioester bond formed between the enzyme’s C149 and the 3-phosphoglycerol moiety of the substrate Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.20.4.1 erythrocyte
-
 Homo sapiens
-
1.20.4.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.20.4.1 arsenate + reduced glutathione + NAD+ + glyceraldehyde-3-phosphate
-
 Homo sapiens arsenite + glutathione + ?
-
 ?
1.20.4.1 arsenate + reduced glutathione + NAD+ + glyceraldehyde-3-phosphate
-
 Rattus norvegicus arsenite + glutathione + ?
-
 ?