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Literature summary extracted from

  • Bozcaarmutlu, A.; Arinc, E.
    Effect of mercury, cadmium, nickel, chromium and zinc on kinetic properties of NADPH-cytochrome P450 reductase purified from leaping mullet (Liza saliens) (2006), Toxicol. in Vitro, 21, 408-416.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.4 Cd2+ 0.05 mM, 66% inhibition. IC50: 0.024 mM, noncompetitive inhibition; 0.05 mM, 66% inhibition, noncompetitive Chelon saliens
1.6.2.4 Cr3+ 0.05 mM,65% inhibition. IC50: 0.033 mM, noncompetitive inhibition; 0.05 mM, 65% inhibition, noncompetitive Chelon saliens
1.6.2.4 Hg2+ 0.05 mM, complete inhibition. IC50: 0.00007 mM, noncompetitive inhibition; 0.05 mM, complete inhibition, noncompetitive Chelon saliens
1.6.2.4 additional information no inhibition by 0.05 mM Zn2+ Chelon saliens
1.6.2.4 Ni2+ 0.05 mM, 37% inhibition. IC50: 0.143 mM, noncompetitive inhibition; 0.05 mM, 37% inhibition, noncompetitive Chelon saliens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.4 microsome
-
 Chelon saliens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Chelon saliens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.2.4
-
 Chelon saliens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.4 liver
-
 Chelon saliens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 2 ferricytochrome c + NADPH
-
 Chelon saliens 2 ferrocytochrome c + NADP+ + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.2.4 NADPH-cytochrome P450 reductase
-
 Chelon saliens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.4 NADPH
-
 Chelon saliens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6.2.4 0.000048
-
 Hg2+
-
 Chelon saliens
1.6.2.4 0.000048
-
 Hg2+ pH 7.7, 24°C Chelon saliens
1.6.2.4 0.0178
-
 Cr3+ pH 7.7, 24°C Chelon saliens
1.6.2.4 0.018
-
 Cr3+
-
 Chelon saliens
1.6.2.4 0.0728
-
 Cd2+ pH 7.7, 24°C Chelon saliens
1.6.2.4 0.073
-
 Cd2+
-
 Chelon saliens
1.6.2.4 0.329
-
 Ni2+
-
 Chelon saliens
1.6.2.4 0.329
-
 Ni2+ pH 7.7, 24°C Chelon saliens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.6.2.4 0.00007
-
 0.05 mM, complete inhibition. IC50: 0.00007 mM, noncompetitive inhibition Chelon saliens Hg2+
1.6.2.4 0.00007
-
 pH 7.7, 24°C Chelon saliens Hg2+
1.6.2.4 0.024
-
 0.05 mM, 66% inhibition. IC50: 0.024 mM, noncompetitive inhibition Chelon saliens Cd2+
1.6.2.4 0.024
-
 pH 7.7, 24°C Chelon saliens Cr3+
1.6.2.4 0.033
-
 0.05 mM,65% inhibition. IC50: 0.033 mM, noncompetitive inhibition Chelon saliens Cr3+
1.6.2.4 0.033
-
 pH 7.7, 24°C Chelon saliens Cd2+
1.6.2.4 0.143
-
 0.05 mM, 37% inhibition. IC50: 0.143 mM, noncompetitive inhibition Chelon saliens Ni2+
1.6.2.4 0.143
-
 pH 7.7, 24°C Chelon saliens Ni2+