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Literature summary extracted from

  • Tokunaga, Y.; Sasaki, H.; Saito, T.
    Clinical role of orotate phosphoribosyl transferase and dihydropyrimidine dehydrogenase in colorectal cancer treated with postoperative fluoropyrimidine (2007), Surgery, 141, 346-353.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.2.10 medicine OPRT expression is negatively associated with colorectal cancer progression Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.10 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens essential enzyme for activation of 5-fluorouracil and its derivatives 5-fluorouridine 5'-phosphate + diphosphate
-
?
2.4.2.10 additional information Homo sapiens relationship between OPRT, antagonizing dihydropyrimidine dehydrogenase, and clinicopathologic features in cancer and treatment with 5-fluorouracil, relation of patients survival and enzyme activities after surgery, detailed overview ?
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?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.10 colonic cancer cell colorectal cancer, 150 patients with cancer at different stages, stage-related enzyme expression level, overview Homo sapiens
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2.4.2.10 colorectal cancer cell
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Homo sapiens
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2.4.2.10 lymph node cancer cell
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Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.10 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
?
2.4.2.10 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate essential enzyme for activation of 5-fluorouracil and its derivatives Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
?
2.4.2.10 additional information relationship between OPRT, antagonizing dihydropyrimidine dehydrogenase, and clinicopathologic features in cancer and treatment with 5-fluorouracil, relation of patients survival and enzyme activities after surgery, detailed overview Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.10 OPRT
-
Homo sapiens
2.4.2.10 orotate phosphoribosyl transferase
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Homo sapiens