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Literature summary extracted from

  • Chapman, J.C.; Polanco, J.R.; Min, S.; Michael, S.D.
    Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: an hypothesis (2005), Reprod. Biol. Endocrinol., 3, 11.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.51 microsome
-
 Mus musculus
-
-
1.1.1.51 mitochondrion
-
 Mus musculus 5739
-
1.1.1.51 additional information the enzyme is distributed between microsomes and mitochondria, the HSD activity in microsomes is predominant throughout the follicular phase of the estrous cycle, the enzyme activity is increased in pregnant mice uteri including embryos, overview Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 pregnenolone + NAD+ Mus musculus the mitochondrial enzyme is essential for the synthesis of progesterone by corpora lutea, overview progesterone + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Mus musculus
-
 female (C3H/HeJ × 129/J)F1 (C31) hybrid mice
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.51 native enzyme partially from ovaries and pregnant uteri including embryos by subcellular fractionation of minced homogenates Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 corpus luteum
-
 Mus musculus
-
1.1.1.51 ovary
-
 Mus musculus
-
1.1.1.51 uterus taken from 10-20 days pregnant mice for enzyme extraction including the embryo Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.51 additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 pregnenolone + NAD+
-
 Mus musculus progesterone + NADH + H+
-
 ?
1.1.1.51 pregnenolone + NAD+ the mitochondrial enzyme is essential for the synthesis of progesterone by corpora lutea, overview Mus musculus progesterone + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 3 beta-hydroxysteroid dehydrogenase
-
 Mus musculus
1.1.1.51 HSD
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.51 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.51 7.4
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NAD+
-
 Mus musculus