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Literature summary extracted from
- Crystal structure of peptide deformylase from Staphylococcus aureus in complex with actinonin, a naturally occurring antibacterial agent (2004), Proteins, 57, 639-642.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.5.1.88 | medicine | target for antibacterial agents against Staphylococcus aureus | Staphylococcus aureus |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.5.1.88 | for expession in Escherichia coli C41(DE3) cells with a C-terminal eight-residue, LEHHHHHH, tag | Staphylococcus aureus |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.5.1.88 | crystal structure of Staphylococcus aureus peptide deformylase, SaPDF, in complex with its inhibitor actinonin at 1.9 A resolution | Staphylococcus aureus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.88 | actinonin | - |
Staphylococcus aureus |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.88 | Zn2+ | - |
Staphylococcus aureus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.88 | formyl-L-methionyl peptide + H2O | Staphylococcus aureus | - |
formate + methionyl peptide | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.88 | Staphylococcus aureus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.1.88 | purified by two chromatographic steps involving affinity and gel filtration columns | Staphylococcus aureus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.88 | formyl-L-methionyl peptide + H2O | - |
Staphylococcus aureus | formate + methionyl peptide | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.88 | - |
Staphylococcus aureus | |
| 3.5.1.88 | peptide deformylase | - |
Staphylococcus aureus |
| 3.5.1.88 | SaPDF | - |
Staphylococcus aureus |
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Release 2023.1 (January 2023)
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