Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Slonimsky, J.D.; Mattaliano, M.D.; Moon, J.I.; Griffith, L.C.; Birren, S.J.
    Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission (2006), Proc. Natl. Acad. Sci. USA, 103, 2915-2919.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin required Mus musculus
2.7.11.17 Calmodulin required Rattus norvegicus
2.7.11.17 additional information brain-derived neurotrophic factor BDNF and nerve growth factor NGF increase the level of activated delta-CaMKII but not alpha-CaMKII, isozyme CaMKIIdelta can be activated by multiple pathways, including via p75 and TrkA, overview Mus musculus
2.7.11.17 additional information brain-derived neurotrophic factor BDNF and nerve growth factor NGF increase the level of activated delta-CaMKII but not alpha-CaMKII, isozyme CaMKIIdelta can be activated by multiple pathways, including via p75 and TrkA, overview Rattus norvegicus
2.7.11.17 neurotrophins have a regulatory role Mus musculus
2.7.11.17 neurotrophins have a regulatory role Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 K42M/T286D inactive CaMKII mutant Mus musculus
2.7.11.17 K42M/T286D inactive CaMKII mutant Rattus norvegicus
2.7.11.17 T286D constitutively active CaMKII mutant Mus musculus
2.7.11.17 T286D constitutively active CaMKII mutant Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 additional information CaMKII isozymes have distinct cellular localizations and function Mus musculus
-
-
2.7.11.17 additional information CaMKII isozymes have distinct cellular localizations and function Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ required Mus musculus
2.7.11.17 Ca2+ required Rattus norvegicus
2.7.11.17 Mg2+
-
 Mus musculus
2.7.11.17 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Mus musculus CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview ?
-
 ?
2.7.11.17 additional information Rattus norvegicus CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Mus musculus
-
 isozymes CaMKII alpha, beta, gamma, and delta
-
2.7.11.17 Rattus norvegicus
-
 isozymes CaMKII alpha, beta, gamma, and delta
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain
-
 Mus musculus
-
2.7.11.17 brain
-
 Rattus norvegicus
-
2.7.11.17 cardiomyocyte neonatal and posterior ventricular cardiac myocytes Mus musculus
-
2.7.11.17 cardiomyocyte neonatal and posterior ventricular cardiac myocytes Rattus norvegicus
-
2.7.11.17 myocyte
-
 Mus musculus
-
2.7.11.17 myocyte
-
 Rattus norvegicus
-
2.7.11.17 neuron neonatal mouse superior cervical ganglion neurons, cultured sympathetic neurons express alpha-, delta-, and gamma-, but not beta-CaMKII mRNA Mus musculus
-
2.7.11.17 neuron neonatal mouse superior cervical ganglion neurons, cultured sympathetic neurons express alpha-, delta-, and gamma-, but not beta-CaMKII mRNA Rattus norvegicus
-
2.7.11.17 neuron sympathetic Mus musculus
-
2.7.11.17 neuron sympathetic Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 additional information CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview Mus musculus ?
-
 ?
2.7.11.17 additional information CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Mus musculus
2.7.11.17 calcium/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
2.7.11.17 CaMKII
-
 Mus musculus
2.7.11.17 CaMKII
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Mus musculus
2.7.11.17 ATP
-
 Rattus norvegicus