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Literature summary extracted from

  • Shafikhani, S.H.; Engel, J.
    Pseudomonas aeruginosa type III-secreted toxin ExoT inhibits host-cell division by targeting cytokinesis at multiple steps (2006), Proc. Natl. Acad. Sci. USA, 103, 15605-15610.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.30 expression of ExoT and the isolated GAP and ADPRT enzyme domains, respectively, in A-549 cells Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 additional information Pseudomonas aeruginosa Pseudomonas aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T-dependent manner, the ADP-ribosyl transferase domain inhibits late steps of cytokinesis by blocking syntaxin-2 localization to the midbody, an event essential for completion of cytokinesis, e.g. in Madin-Darby canine kidney cells, mechanism, overview ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Pseudomonas aeruginosa
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 additional information Pseudomonas aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T-dependent manner, the ADP-ribosyl transferase domain inhibits late steps of cytokinesis by blocking syntaxin-2 localization to the midbody, an event essential for completion of cytokinesis, e.g. in Madin-Darby canine kidney cells, mechanism, overview Pseudomonas aeruginosa ?
-
 ?
2.4.2.30 additional information ExoT is a bifunctional type III secretion system effector protein that contains an N-terminal GTPase-activating protein domain and a C-terminal ADP-ribosyl transferase domain Pseudomonas aeruginosa ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.30 More the bifunctional ExoT contains an N-terminal GTPase-activating protein domain, GAP domain, and a C-terminal ADP-ribosyl transferase domain, ADPRT domain Pseudomonas aeruginosa

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 ExoT
-
 Pseudomonas aeruginosa
2.4.2.30 type III-secreted toxin
-
 Pseudomonas aeruginosa