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Literature summary extracted from

  • Basu, N.K.; Kovarova, M.; Garza, A.; Kubota, S.; Saha, T.; Mitra, P.S.; Banerjee, R.; Rivera, J.; Owens, I.S.
    Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity (2005), Proc. Natl. Acad. Sci. USA, 102, 6285-6290.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression in Cos-1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.17 S432G mutant enzyme retains full activity, shift in pH-optimum for glucuronidation of eugenol from pH 6.0 for wild-type enzyme to 6.4 for mutant enzyme S432G Homo sapiens
2.4.1.17 S432G shift in pH-optimum for glucuronidation of eugenol from pH 8.5 for wild-type enzyme to 6.4 for mutant enzyme S432G. S432G-UGT1A7, but not wild-type UGT1A7, metabolizes new substrates, 17beta-estradiol, flurbiprofen, and estriol Homo sapiens
2.4.1.17 T202A inactive mutant enzyme Homo sapiens
2.4.1.17 T73A inactive mutant enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens Q9HAW7
-
-
2.4.1.17 Homo sapiens Q9HAW8
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.17 phosphoprotein phosphorylation of a UDP-glucuronosyltransferase by protein kinase C regulates substrate specificity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 17beta-estradiol + UDP-glucuronate metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 Homo sapiens ?
-
 ?
2.4.1.17 estriol + UDP-glucuronate metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 Homo sapiens ?
-
 ?
2.4.1.17 eugenol + UDP-glucuronate
-
 Homo sapiens ?
-
 ?
2.4.1.17 eugenol + UDP-glucuronate
-
 Homo sapiens UDP + eugenol-O-alpha-D-glucuronide
-
 ?
2.4.1.17 flurbiprofen + UDP-glucuronate metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UGT1A10
-
 Homo sapiens
2.4.1.17 UGT1A7
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 6
-
 substrate: eugenol, wild-type enzyme Homo sapiens
2.4.1.17 6.4
-
 substrate: eugenol, mutant enzyme S432G Homo sapiens
2.4.1.17 8.5
-
 substrate: eugenol, wild-type enzyme Homo sapiens