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Literature summary extracted from

  • Kim, S.; Kuzuyama, T.; Chang, Y.; Song, K.; Kim, S.
    Identification of class 2 1-deoxy-D-xylulose 5-phosphate synthase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase genes from Ginkgo biloba and their transcription in embryo culture with respect to ginkgolide biosynthesis (2006), Planta Med., 72, 234-240.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.267 DNA and amino acid sequence determination and analysis, phylogenetic tree, functional complementation of Escherichia coli DXR-knockout mutants Ginkgo biloba
2.2.1.7 gene dxs2, cloning from embryonic roots, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in and complementation of an enzyme-deficient Escherichia coli mutant strain Ginkgo biloba

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.267 additional information rescuing of Escherichia coli enzyme-knockout mutants by the Ginkgo gene clone from embryonic roots Ginkgo biloba

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ Ginkgo biloba the enzyme catalyzes the second committed step in the 2C-methyl-D-erythritol 4-phosphate pathway for biosynthesis of isopentenyl diphosphate 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ?
2.2.1.7 additional information Ginkgo biloba gingkolides are diterpenoids and potent platelet-activating factor antagonists ?
-
 ?
2.2.1.7 pyruvate + D-glyceraldehyde 3-phosphate Ginkgo biloba the enzyme catalyzes the first committed step in the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway which leads to the biosynthesis of gingkolides, overview, gingkolides are synthesized in roots and then translocated to the leaves 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.267 Ginkgo biloba Q5J7B3 DXR-like mRNA
-
2.2.1.7 Ginkgo biloba Q5J7B4 gene dxs1 and dxs2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.267 embryo root Ginkgo biloba
-
1.1.1.267 leaf
-
 Ginkgo biloba
-
1.1.1.267 root embryonic, higher expression level Ginkgo biloba
-
2.2.1.7 embryo culture Ginkgo biloba
-
2.2.1.7 leaf DXS1 Ginkgo biloba
-
2.2.1.7 additional information DXS2 is exclusively expressed in embryonic roots, while DXS1 is expressed to a higher extent in leaves Ginkgo biloba
-
2.2.1.7 root
-
 Ginkgo biloba
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+
-
 Ginkgo biloba 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ?
1.1.1.267 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ the enzyme catalyzes the second committed step in the 2C-methyl-D-erythritol 4-phosphate pathway for biosynthesis of isopentenyl diphosphate Ginkgo biloba 2-C-methyl-D-erythritol 4-phosphate + NADP+
-
 ?
2.2.1.7 additional information gingkolides are diterpenoids and potent platelet-activating factor antagonists Ginkgo biloba ?
-
 ?
2.2.1.7 pyruvate + D-glyceraldehyde 3-phosphate
-
 Ginkgo biloba 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?
2.2.1.7 pyruvate + D-glyceraldehyde 3-phosphate the enzyme catalyzes the first committed step in the 2C-methyl-D-erythritol-4-phosphate, MEP, pathway which leads to the biosynthesis of gingkolides, overview, gingkolides are synthesized in roots and then translocated to the leaves Ginkgo biloba 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.267 1-deoxy-D-xylulose 5-phosphate reductoisomerase
-
 Ginkgo biloba
1.1.1.267 DXR
-
 Ginkgo biloba
2.2.1.7 DXS
-
 Ginkgo biloba

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.267 NADPH
-
 Ginkgo biloba