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Literature summary extracted from

  • Claeyssen, E.; Rivoal, J.
    Isozymes of plant hexokinase: occurrence, properties and functions (2007), Phytochemistry, 68, 709-731.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 ADP 0.1 mM, 60% inhibition Capsicum chacoense
2.7.1.1 ADP 1 mM, 50% inhibition; about 50% inhibition at 1 mM Pisum sativum
2.7.1.1 ADP 0.1 mM, 60% inhibition Solanum chacoense
2.7.1.1 ADP 5 mM, about 50% inhibition Solanum lycopersicum
2.7.1.1 ADP hexokinase 1 Solanum tuberosum
2.7.1.1 ADP
-
 Triticum aestivum
2.7.1.1 ADP 1 mM, 45% inhibition, enzyme from kernel. Inhibits non-cytosolic enzyme from root. No inhibition of the cytosolic enzyme from root; inhibition of non-cytosolic enzyme, no inhibition of cytosolic enzyme Zea mays
2.7.1.1 D-glucose 6-phosphate
-
 Solanum lycopersicum
2.7.1.1 D-glucose 6-phosphate hexokinase 1 Solanum tuberosum
2.7.1.1 D-glucose 6-phosphate weak inhibition of enzyme from kernel. No effect on the enzyme from root; weak inhibition of enzyme from kernel, no inhibition of cytosolic and non-cytosolic enzyme from root Zea mays
2.7.1.1 mannoheptulose
-
 Solanum lycopersicum
2.7.1.1 mannoheptulose inhibition of non-cytosolic enzyme and cytosolic enzyme Zea mays
2.7.1.1 additional information no inhibition by D-glucose 6-phosphate and D-trehalose 6-phosphate Capsicum chacoense
2.7.1.1 additional information D-glucose 6-phosphate has no effect on the enzyme from seed Pisum sativum
2.7.1.1 additional information D-glucose 6-phosphate has no effect Solanum chacoense
2.7.1.1 additional information D-glucose 6-phosphate has no effect; no inhibition of hexokinase 2: D-glucose 6-phosphate Solanum tuberosum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.1 cytosol
-
 Zea mays 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Arabidopsis thaliana Q9FZG4
-
-
2.7.1.1 Capsicum chacoense
-
 recombinant
-
2.7.1.1 Pisum sativum
-
-
-
2.7.1.1 Saccharomyces cerevisiae
-
-
-
2.7.1.1 Solanum chacoense
-
-
-
2.7.1.1 Solanum lycopersicum
-
-
-
2.7.1.1 Solanum tuberosum
-
-
-
2.7.1.1 Solanum tuberosum O64390
-
-
2.7.1.1 Solanum tuberosum Q9SQ76
-
-
2.7.1.1 Triticum aestivum
-
-
-
2.7.1.1 Zea mays
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 germ
-
 Triticum aestivum
-
2.7.1.1 germ
-
 Capsicum chacoense
-
2.7.1.1 kernel
-
 Zea mays
-
2.7.1.1 root
-
 Zea mays
-
2.7.1.1 seed
-
 Pisum sativum
-
2.7.1.1 tuber
-
 Solanum tuberosum
-
2.7.1.1 tuber
-
 Solanum chacoense
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 ATP + D-glucose
-
 Triticum aestivum ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-glucose
-
 Pisum sativum ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-glucose
-
 Zea mays ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-glucose
-
 Solanum tuberosum ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-glucose
-
 Capsicum chacoense ADP + D-glucose 6-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.1 hexokinase 1
-
 Solanum tuberosum
2.7.1.1 hexokinase 2
-
 Solanum tuberosum
2.7.1.1 HK1
-
 Solanum tuberosum
2.7.1.1 HK2
-
 Solanum tuberosum
2.7.1.1 ScHK2
-
 Solanum chacoense
2.7.1.1 ScHK2
-
 Capsicum chacoense
2.7.1.1 ScHK2
-
 Arabidopsis thaliana

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.1 0.03
-
 ADP non-cytosolic hexokinase from root Zea mays
2.7.1.1 0.03
-
 ADP root, non-cytosolic enzyme Zea mays
2.7.1.1 0.04
-
 ADP
-
 Solanum tuberosum
2.7.1.1 0.04
-
 ADP hexokinase 1 Solanum tuberosum
2.7.1.1 0.11
-
 ADP
-
 Solanum tuberosum
2.7.1.1 0.11
-
 ADP hexokinase 2 Solanum tuberosum
2.7.1.1 0.5
-
 mannoheptulose non-cytoslic hexokinase from root Zea mays
2.7.1.1 0.5
-
 mannoheptulose non-cytosolic enzyme Zea mays
2.7.1.1 1
-
 ADP
-
 Triticum aestivum
2.7.1.1 4
-
 D-glucose 6-phosphate pH 7, hexokinase 1 Solanum tuberosum
2.7.1.1 20
-
 mannoheptulose cytosolic enzyme Zea mays
2.7.1.1 20
-
 mannoheptulose cytosolic hexokinase from root Zea mays