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Literature summary extracted from

  • Tasdemir, D.; Guener, N.D.; Perozzo, R.; Brun, R.; Doenmez, A.A.; Calis, I.; Rueedi, P.
    Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots (2005), Phytochemistry, 66, 355-362.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.9 medicine anti-malarial target Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 iridoid aglycone IC50: 40.6 microg/ml, isolated form the extract of Scrophularia lepidota roots Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.9 acyl-[acyl-carrier protein] + NAD+ Plasmodium falciparum
-
 trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 acyl-[acyl-carrier protein] + NAD+
-
 Plasmodium falciparum trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?
1.3.1.9 crotonyl-CoA + NADH + H+ activity assay Plasmodium falciparum butyryl-CoA + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl-ACP reductase
-
 Plasmodium falciparum
1.3.1.9 enoyl-[acyl-carrier-protein] reductase
-
 Plasmodium falciparum
1.3.1.9 FabI
-
 Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.9 7.4
-
 activity assay Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NADH
-
 Plasmodium falciparum