Literature summary extracted from

Ambrozin, A.R.; Leite, A.C.; Silva, M.; Vieira, P.C.; Fernandes, J.B.; Thiemann, O.H.; da Silva, M.F.; Oliva, G.
Screening of Leishmania APRT enzyme inhibitors (2005), Pharmazie, 60, 781-784.

Application

EC Number	Application	Comment	Organism
2.4.2.7	drug development	the enzyme is a target for antileishmanicidal drug development	Leishmania tarentolae

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.4.2.7	isodutaduprine	alkaloid from Almeidea rubra, 21.6% inhibition at 0.0356 mM of the recombinant enzyme	Leishmania tarentolae
2.4.2.7	isokokusagine	alkaloid from Almeidea rubra, 44.6% inhibition at 0.0412 mM of the recombinant enzyme	Leishmania tarentolae
2.4.2.7	isoskimmianine	alkaloid from Almeidea rubra, 39.1% inhibition at 0.0386 mM of the recombinant enzyme	Leishmania tarentolae
2.4.2.7	additional information	methanolic and hexanic extracts from roots and leaves of Cedrela fissilis and from fruits, branches and leaves of Cipadessa fruticosa show strong antileishmanicidal activities, the inhibitory activities of plant organ extracts with dichloromethane are lower, overview	Leishmania tarentolae

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
2.4.2.7	Mg2+	-	Leishmania tarentolae

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.2.7	Leishmania tarentolae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.2.7	5-phospho-alpha-D-ribosyl-1-diphosphate + adenine	-	Leishmania tarentolae	AMP + diphosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.2.7	APRT	-	Leishmania tarentolae

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.4.2.7	25	-	assay at	Leishmania tarentolae

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.4.2.7	7.4	-	assay at	Leishmania tarentolae

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Release 2023.1 (January 2023)