EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.17 | UGT1A1 that contains the Y486D mutation (1A1 numbering) is expressed as His-tagged protein in thebaculovirus-infected insect cells | Homo sapiens |
2.4.1.17 | UGT1A6 that contains the Y485D is expressed as His-tagged protein in thebaculovirus-infected insect cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.4.1.17 | Y485D | mutation lowers the normalized glucuronidation rate to 6% when the aglycone substrate is 1-naphthol. Km of the mutant enzyme for UDP-glucuronic acid is about 50 times higher than in UGT1A6. Coexpression of UGT1A6(Y485D) with UGT1A4 lowers the Km for UDP-glucuronic acid to the level of UGT1A6 | Homo sapiens |
2.4.1.17 | Y486D | mutation lowers the normalized glucuronidation rate to 13% when the aglycone substrate is 1-naphthol | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.17 | Homo sapiens | P19224 | - |
- |
2.4.1.17 | Homo sapiens | P22309 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.17 | 1-naphthol + UDP-glucuronate | - |
Homo sapiens | UDP + naphth-1-yl-beta-D-glucuronide | - |
? | |
2.4.1.17 | serotonin + UDP-glucuronate | coexpression of UGT1A6 with UGT2B7 influences wild-type UGT1A6, increasing the normalized activity of UGT1A6 | Homo sapiens | UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.1.17 | More | hetero-oligomerization may play an important role in UDP-glucuronosyltransferases activity | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.17 | UGT1A1 | - |
Homo sapiens |
2.4.1.17 | UGT1A6 | - |
Homo sapiens |