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Literature summary extracted from

  • Nowell, S.; Falany, C.N.
    Pharmacogenetics of human cytosolic sulfotransferases (2006), Oncogene, 25, 1673-1678.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 SULT1A1, DNA and amino acid sequence determination and analysis, genotyping, determination and sequence analysis of putative transcription factor binding sites, SULT1A1 promoter haplotype frequencies in African-American, Caucasian, and Chinese individuals, overview Homo sapiens
2.8.2.15 expression and expression analysis of wild-type and mutant SULT2A1 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.8.2.15 A679G naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview Homo sapiens
2.8.2.15 G187C naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview Homo sapiens
2.8.2.15 G781A naturally occuring polymorphisms of SULT2A1, genotyping, SULT2A1 variant allele frequencies in African-American populations, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 2-methoxyestradiol Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen Homo sapiens a potent inducer of apoptosis in breast tumor cell lines adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol Homo sapiens
-
 adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + acetaminophen Homo sapiens
-
 adenosine 3',5'-bisphosphate + 4-(acetylamino)phenylsulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + minoxidil Homo sapiens
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 additional information Homo sapiens SULT1A1 sulfates a wide variety of phenolic xenobiotics, as well as iodothyronines, and also certain N-hydroxy heterocyclic and aromatic amines, SULT1A1 is a detoxifying enzyme, overview ?
-
 ?
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
 ?
2.8.2.15 additional information Homo sapiens SULT2A1 plays a very important role in formation of steroid sulfate esters, and sulfates both 3alpha- and 3beta-hydroxysteroids, estrogens, testosterone, and aliphatic hydroxyl-containing drugs and xenobiotics ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens P50225 SULT1A1
-
2.8.2.15 Homo sapiens
-
 SULT2A1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 blood platelet expression of SULT1A1, activity varies with gender and season, platelet phenotypes, overview Homo sapiens
-
2.8.2.1 liver high expression level of SULT1A1 Homo sapiens
-
2.8.2.15 adrenal gland fetal, and adult adrenal reticular layer as well as adrenal cortex, SULT2A1 Homo sapiens
-
2.8.2.15 liver SULT2A1 Homo sapiens
-
2.8.2.15 additional information variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 2-methoxyestradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen a potent inducer of apoptosis in breast tumor cell lines Homo sapiens adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + acetaminophen
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-(acetylamino)phenylsulfate
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + minoxidil
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 additional information SULT1A1 sulfates a wide variety of phenolic xenobiotics, as well as iodothyronines, and also certain N-hydroxy heterocyclic and aromatic amines, SULT1A1 is a detoxifying enzyme, overview Homo sapiens ?
-
 ?
2.8.2.1 additional information SULT1A1 catalyzes the sulfation of the active metabolizes of tamoxifen and endoxifen Homo sapiens ?
-
 ?
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
 ?
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone variant haplotypes in tissues possessing alterations in activity or stability may alter the plasma levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate thereby altering the conversion of dehydroepiandrosterone in tissues, overview Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
 ?
2.8.2.15 additional information SULT2A1 plays a very important role in formation of steroid sulfate esters, and sulfates both 3alpha- and 3beta-hydroxysteroids, estrogens, testosterone, and aliphatic hydroxyl-containing drugs and xenobiotics Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT1A1
-
 Homo sapiens
2.8.2.15 dehydroepiandrosterone sulfotransferase
-
 Homo sapiens
2.8.2.15 SULT2A1
-
 Homo sapiens