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Literature summary extracted from

  • Liekens, S.; Balzarini, J.; Hernandez, A.I.; De Clercq, E.; Priego, E.M.; Camarasa, M.J.; Perez-Perez, M.J.
    Thymidine phosphorylase is noncompetitively inhibited by 5-O-trityl-inosine (KIN59) and related compounds (2006), Nucleosides Nucleotides Nucleic Acids, 25, 975-980.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 5'-O-trityl-inosine IC50: 0.044 mM, reversible, noncompetitive inhibition with respect to thymidine and phosphate Escherichia coli
2.4.2.4 5'-O-trityl-inosine IC50: 0.067 mM, reversible, noncmpetitive Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Escherichia coli
-
-
-
2.4.2.4 Homo sapiens P19971
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 thymidine + phosphate
-
 Escherichia coli thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.4 Tpase
-
 Escherichia coli
2.4.2.4 Tpase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.4 0.039
-
 5'-O-trityl-inosine against thymidine Escherichia coli
2.4.2.4 0.146
-
 5'-O-trityl-inosine against phosphate Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.2.4 0.044
-
 IC50: 0.044 mM, reversible, noncompetitive inhibition with respect to thymidine and phosphate Escherichia coli 5'-O-trityl-inosine
2.4.2.4 0.067
-
 IC50: 0.067 mM, reversible, noncmpetitive Homo sapiens 5'-O-trityl-inosine