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Literature summary extracted from

  • Kamiya, H.; Ochiai, H.; Harashima, H.; Ito, M.; Matsuda, A.
    Transient expression of Drosophila melanogaster deoxynucleoside kinase gene enhances cytotoxicity of nucleoside analogs (2006), Nucleosides Nucleotides Nucleic Acids, 25, 553-560.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.145 medicine deoxynucleoside kinase gene is introduced into HeLa cells with cationic lipids, to allow its transient expression. Cytotoxicities of 1-beta-D-arabinofuranosylcytosine, 5-fluorodeoxyuridine, and 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytosine are increased by the deoxynucleoside kinase gene. The combination of the transient expression of the Drosophila deoxynucleoside kinase gene and these nucleoside analogs is a candidate for suicide gene therapy Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.145 deoxynucleoside kinase gene is introduced into HeLa cells with cationic lipids, to allow its transient expression. Cytotoxicities of 1-beta-D-arabinofuranosylcytosine, 5-fluorodeoxyuridine, and 1-(2-deoxy-2-methylene-beta-D-erythro-pentofuranosyl)cytosine are increased by the deoxynucleoside kinase gene. The combination of the transient expression of the Drosophila deoxynucleoside kinase gene and these nucleoside analogs is a candidate for suicide gene therapy Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.145 Drosophila melanogaster
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.145 additional information transient expression of Drosophila melanogaster deoxynucleoside kinase gene in HeLa cells enhances cytotoxicity of nucleoside analogs Drosophila melanogaster ?
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