2.7.1.74
0.003
(-)-beta-2',3'-dideoxy-3'-thiacytidine
wild type enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0034
ATP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.008
(-)-beta-2',3'-dideoxy-3'-thiacytidine
C9S/C45S/C59S/C146S mutant enzyme with ATP as phosphate donor, 37°C, pH 7.5; wild type enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.008
UTP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0084
ATP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0106
UTP
cosubstrate troxacitabine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.011
troxacitabine
wild type enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.013
troxacitabine
wild type enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0132
ATP
cosubstrate troxacitabine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0149
UTP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.015
(-)-beta-2',3'-dideoxy-3'-thiacytidine
C9S/C45S/C59S/C146S mutant enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0568
ATP
cosubstrate troxacitabine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.057
troxacitabine
C9S/C45S/C59S/C146S mutant enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0578
UTP
cosubstrate troxacitabine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.058
troxacitabine
C9S/C45S/C59S/C146Smutant enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
ATP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
676221
Homo sapiens
ADP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
?
2.7.1.74
ATP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
i.e. lamivudine
676221
Homo sapiens
ADP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
?
2.7.1.74
ATP + D-2'-deoxycytidine
676221
Homo sapiens
ADP + D-2'-deoxycytidine 5'-phosphate
?
2.7.1.74
ATP + L-2'-deoxycytidine
676221
Homo sapiens
ADP + L-2'-deoxycytidine 5'-phosphate
?
2.7.1.74
ATP + troxacitabine
676221
Homo sapiens
ADP + troxacitabine 5'-phosphate
?
2.7.1.74
additional information
dCK is able to phosphorylate both D- and L-nucleosides and nucleoside analogs
676221
Homo sapiens
?
2.7.1.74
NTP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
activation of the clinically relevant substrate
676221
Homo sapiens
NDP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
?
2.7.1.74
NTP + troxacitabine
activation of the clinically relevant substrate
676221
Homo sapiens
?
?
2.7.1.74
UTP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
676221
Homo sapiens
UDP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
?
2.7.1.74
UTP + D-2'-deoxycytidine
676221
Homo sapiens
UDP + D-2'-deoxycytidine 5'-phosphate
?
2.7.1.74
UTP + L-2'-deoxycytidine
676221
Homo sapiens
UDP + L-2'-deoxycytidine 5'-phosphate
?
2.7.1.74
UTP + troxacitabine
676221
Homo sapiens
UDP + troxacitabine 5'-phosphate
?
2.7.1.74
0.01
UTP
cosubstrate L-2'-deoxycytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.012
ATP
cosubstrate L-2'-deoxycytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.028
ATP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.028
(-)-beta-2',3'-dideoxy-3'-thiacytidine
C9S/C45S/C59S/C146S mutant enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.03
ATP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.03
(-)-beta-2',3'-dideoxy-3'-thiacytidine
wild type enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.033
ATP
cosubstrate D-2'-deoxycytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.036
ATP
cosubstrate L-2'-deoxycytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.042
UTP
cosubstrate L-2'-deoxycytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.049
UTP
cosubstrate D-2'-deoxycytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.072
(-)-beta-2',3'-dideoxy-3'-thiacytidine
C9S/C45S/C59S/C146S mutant enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.072
UTP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.095
ATP
cosubstrate troxacitabine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.095
troxacitabine
wild type enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.102
(-)-beta-2',3'-dideoxy-3'-thiacytidine
wild type enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.102
UTP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.173
ATP
cosubstrate D-2'-deoxycytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.179
UTP
cosubstrate troxacitabine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.192
ATP
cosubstrate troxacitabine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.192
troxacitabine
C9S/C45S/C59S/C146S mutant enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.217
UTP
cosubstrate D-2'-deoxycytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.524
UTP
cosubstrate troxacitabine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
6.08
troxacitabine
C9S/C45S/C59S/C146S mutant enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.003
(-)-beta-2',3'-dideoxy-3'-thiacytidine
wild type enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0034
ATP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.008
(-)-beta-2',3'-dideoxy-3'-thiacytidine
C9S/C45S/C59S/C146S mutant enzyme with ATP as phosphate donor, 37°C, pH 7.5; wild type enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.008
UTP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0084
ATP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0106
UTP
cosubstrate troxacitabine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.011
troxacitabine
wild type enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.013
troxacitabine
wild type enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0132
ATP
cosubstrate troxacitabine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0149
UTP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.015
(-)-beta-2',3'-dideoxy-3'-thiacytidine
C9S/C45S/C59S/C146S mutant enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0568
ATP
cosubstrate troxacitabine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.057
troxacitabine
C9S/C45S/C59S/C146S mutant enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.0578
UTP
cosubstrate troxacitabine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.058
troxacitabine
C9S/C45S/C59S/C146Smutant enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
ATP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
676221
Homo sapiens
ADP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
?
2.7.1.74
ATP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
i.e. lamivudine
676221
Homo sapiens
ADP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
?
2.7.1.74
ATP + D-2'-deoxycytidine
676221
Homo sapiens
ADP + D-2'-deoxycytidine 5'-phosphate
?
2.7.1.74
ATP + L-2'-deoxycytidine
676221
Homo sapiens
ADP + L-2'-deoxycytidine 5'-phosphate
?
2.7.1.74
ATP + troxacitabine
676221
Homo sapiens
ADP + troxacitabine 5'-phosphate
?
2.7.1.74
additional information
dCK is able to phosphorylate both D- and L-nucleosides and nucleoside analogs
676221
Homo sapiens
?
2.7.1.74
NTP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
activation of the clinically relevant substrate
676221
Homo sapiens
NDP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
?
2.7.1.74
NTP + troxacitabine
activation of the clinically relevant substrate
676221
Homo sapiens
?
?
2.7.1.74
UTP + (-)-beta-2',3'-dideoxy-3'-thiacytidine
676221
Homo sapiens
UDP + (-)-beta-2',3'-dideoxy-3'-thiacytidine 5'-phosphate
?
2.7.1.74
UTP + D-2'-deoxycytidine
676221
Homo sapiens
UDP + D-2'-deoxycytidine 5'-phosphate
?
2.7.1.74
UTP + L-2'-deoxycytidine
676221
Homo sapiens
UDP + L-2'-deoxycytidine 5'-phosphate
?
2.7.1.74
UTP + troxacitabine
676221
Homo sapiens
UDP + troxacitabine 5'-phosphate
?
2.7.1.74
0.01
UTP
cosubstrate L-2'-deoxycytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.012
ATP
cosubstrate L-2'-deoxycytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.028
ATP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.028
(-)-beta-2',3'-dideoxy-3'-thiacytidine
C9S/C45S/C59S/C146S mutant enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.03
ATP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.03
(-)-beta-2',3'-dideoxy-3'-thiacytidine
wild type enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.033
ATP
cosubstrate D-2'-deoxycytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.036
ATP
cosubstrate L-2'-deoxycytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.042
UTP
cosubstrate L-2'-deoxycytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.049
UTP
cosubstrate D-2'-deoxycytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.072
(-)-beta-2',3'-dideoxy-3'-thiacytidine
C9S/C45S/C59S/C146S mutant enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.072
UTP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.095
ATP
cosubstrate troxacitabine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.095
troxacitabine
wild type enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.102
(-)-beta-2',3'-dideoxy-3'-thiacytidine
wild type enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.102
UTP
cosubstrate (-)-beta-2',3'-dideoxy-3'-thiacytidine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.173
ATP
cosubstrate D-2'-deoxycytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.179
UTP
cosubstrate troxacitabine, wild-type, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.192
ATP
cosubstrate troxacitabine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.192
troxacitabine
C9S/C45S/C59S/C146S mutant enzyme with ATP as phosphate donor, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.217
UTP
cosubstrate D-2'-deoxycytidine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
0.524
UTP
cosubstrate troxacitabine, mutant C9S/C45S/C59S/C146S, 37°C, pH 7.5
Homo sapiens
2.7.1.74
6.08
troxacitabine
C9S/C45S/C59S/C146S mutant enzyme with UTP as phosphate donor, 37°C, pH 7.5
Homo sapiens