EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.5.1.1 | ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | Homo sapiens | ligation of DNA is the ultimate step in DNA repair to restore genome integrity. Ligase I and III accumulate at DNA repair sites. DNA Ligase III accumulates at microirradiated sites before DNA ligase. Recruitment of DNA ligase I to sites of DNA damage depends on its interaction with PCNA | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.5.1.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
6.5.1.1 | HeLa cell | introduction of DNA lesions in human cells by laser microirradiation. DNA ligase I and III accumulate at DNA repair sites. DNA Ligase III accumulates at microirradiated sites before DNA ligase I. Recruitment of DNA ligase I to sites of DNA damage depends on its interaction with PCNA | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.5.1.1 | ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | ligation of DNA is the ultimate step in DNA repair to restore genome integrity. Ligase I and III accumulate at DNA repair sites. DNA Ligase III accumulates at microirradiated sites before DNA ligase. Recruitment of DNA ligase I to sites of DNA damage depends on its interaction with PCNA | Homo sapiens | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.5.1.1 | DNA ligase I | - |
Homo sapiens |