EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.2.30 | gene parp-1, expression in LMV cells and subclones, derived from the parental line LLC-MK2 from rhesus monkey Macaca mulatta kidney, stably expressing the estradiol-inducible transcriptional transactivation factor Gal4ERVP | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.4.2.30 | additional information | downregulatory effect of PARP-1 on the p53-dependent regulation of recombination between SV40 minichromosomes in primate cell lines conditionally expressing exogenous PARP-1 in a wild-type p53-positive or -negative background, respectively, overview | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.30 | additional information | Mus musculus | PARP-1 plays fundamental roles in the recruitment and modulation of enzymatic and regulatory factors involved in transcription, DNA replication, repair and recombination, the enzyme antagonizes topoisomerase I-dependent recombination stimulation by P53 | ? | - |
? | |
2.4.2.30 | NAD+ + (ADP-D-ribosyl)n-acceptor | Mus musculus | - |
nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
2.4.2.30 | NAD+ + p53 | Mus musculus | - |
nicotinamide + (ADP-D-ribosyl)-p53 | - |
? | |
2.4.2.30 | NAD+ + topoisomerase I | Mus musculus | - |
nicotinamide + (ADP-D-ribosyl)-topoisomerase I | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.30 | Mus musculus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.30 | additional information | PARP-1 plays fundamental roles in the recruitment and modulation of enzymatic and regulatory factors involved in transcription, DNA replication, repair and recombination, the enzyme antagonizes topoisomerase I-dependent recombination stimulation by P53 | Mus musculus | ? | - |
? | |
2.4.2.30 | NAD+ + (ADP-D-ribosyl)n-acceptor | - |
Mus musculus | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
2.4.2.30 | NAD+ + p53 | - |
Mus musculus | nicotinamide + (ADP-D-ribosyl)-p53 | - |
? | |
2.4.2.30 | NAD+ + p53 | PARP-1 interacts with and poly(ADP-ribosyl)ates p53, which participates in DNA recombination | Mus musculus | nicotinamide + (ADP-D-ribosyl)-p53 | - |
? | |
2.4.2.30 | NAD+ + topoisomerase I | - |
Mus musculus | nicotinamide + (ADP-D-ribosyl)-topoisomerase I | - |
? | |
2.4.2.30 | NAD+ + topoisomerase I | PARP-1 interacts with and poly(ADP-ribosyl)ates topoisomerase I, which participates in DNA recombination, I-SceI-meganuclease-mediated cleavage terminates the interaction, overview | Mus musculus | nicotinamide + (ADP-D-ribosyl)-topoisomerase I | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.2.30 | PARP-1 | - |
Mus musculus |
2.4.2.30 | poly(ADP-ribose) polymerase-1 | - |
Mus musculus |