Literature summary extracted from

Hong, K.W.; Sugawara, Y.; Hasegawa, H.; Hayasaka, I.; Hashimoto, R.; Ito, S.; Inoue-Murayama, M.
A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats (2007), Neurosci. Lett., 412, 195-200.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.16.4	expression in HeLa cells	Homo sapiens
1.14.16.4	expression in HeLa cells	Rattus norvegicus
1.14.16.4	TPH2, DNA and amino acid sequence determination and analysis, genotyping, expression of mutant Q468R in HeLa cells, overview	Pan troglodytes

EC Number	Protein Variants	Comment	Organism
1.14.16.4	C164A/G170A	mutations represent differences between the human and chimpanzee enzyme, activity similar to wild-type	Homo sapiens
1.14.16.4	C164A/G170A/Q468R	mutations represent differences between the human and chimpanzee enzyme and a polymorphism at position 468 present in chimpanzees but not in humans. 1.4fold activity compared to wild-type	Homo sapiens
1.14.16.4	Q486R	determination of a naturally occuring single nucleotide polymorphism at the exon 11 coding region that resulted in amino acid substitutions in the C-terminal domain, determination of allele frequency, the mutation is a gain -of-function mutation leading to 20% increased activity, comparison to rat and human TPH2s, overview	Pan troglodytes

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.16.4	L-tryptophan + tetrahydrobiopterin + O2	Pan troglodytes	TPH2 is a rate-limiting enzyme of neuronal serotonin biosynthesis	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

EC Number	Organism	UniProt	Comment	Textmining
1.14.16.4	Callithrix jacchus	-	-	-
1.14.16.4	Cephalopachus bancanus	-	-	-
1.14.16.4	Gorilla gorilla	-	-	-
1.14.16.4	Homo sapiens	-	-	-
1.14.16.4	Hylobates agilis	-	-	-
1.14.16.4	Macaca fuscata	-	-	-
1.14.16.4	Mandrillus sphinx	-	-	-
1.14.16.4	Otolemur crassicaudatus	-	-	-
1.14.16.4	Pan troglodytes	-	-	-
1.14.16.4	Pongo pygmaeus	-	-	-
1.14.16.4	Rattus norvegicus	-	-	-

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.16.4	cell culture	-	Homo sapiens	-
1.14.16.4	cell culture	-	Rattus norvegicus	-

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
1.14.16.4	L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	-	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
1.14.16.4	L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	1.3fold activity compared to the human tryptophan hydroxylase 2	Rattus norvegicus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
1.14.16.4	L-tryptophan + tetrahydrobiopterin + O2	-	Pan troglodytes	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
1.14.16.4	L-tryptophan + tetrahydrobiopterin + O2	TPH2 is a rate-limiting enzyme of neuronal serotonin biosynthesis	Pan troglodytes	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

EC Number	Synonyms	Comment	Organism
1.14.16.4	TPH2	-	Homo sapiens
1.14.16.4	TPH2	-	Rattus norvegicus
1.14.16.4	TPH2	-	Macaca fuscata
1.14.16.4	TPH2	-	Pan troglodytes
1.14.16.4	TPH2	-	Callithrix jacchus
1.14.16.4	TPH2	-	Pongo pygmaeus
1.14.16.4	TPH2	-	Cephalopachus bancanus
1.14.16.4	TPH2	-	Otolemur crassicaudatus
1.14.16.4	TPH2	-	Gorilla gorilla
1.14.16.4	TPH2	-	Hylobates agilis
1.14.16.4	TPH2	-	Mandrillus sphinx
1.14.16.4	tryptophan hydroxylase 2	-	Homo sapiens
1.14.16.4	tryptophan hydroxylase 2	-	Rattus norvegicus
1.14.16.4	tryptophan hydroxylase 2	-	Macaca fuscata
1.14.16.4	tryptophan hydroxylase 2	-	Pan troglodytes
1.14.16.4	tryptophan hydroxylase 2	-	Callithrix jacchus
1.14.16.4	tryptophan hydroxylase 2	-	Pongo pygmaeus
1.14.16.4	tryptophan hydroxylase 2	-	Cephalopachus bancanus
1.14.16.4	tryptophan hydroxylase 2	-	Otolemur crassicaudatus
1.14.16.4	tryptophan hydroxylase 2	-	Gorilla gorilla
1.14.16.4	tryptophan hydroxylase 2	-	Hylobates agilis
1.14.16.4	tryptophan hydroxylase 2	-	Mandrillus sphinx