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Literature summary extracted from

  • Paley, E.L.; Denisova, G.; Sokolova, O.; Posternak, N.; Wang, X.; Brownell, A.L.
    Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models (2007), Neuromolecular Med., 9, 55-82.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.1.1.2 additional information tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, overview Homo sapiens
6.1.1.2 additional information tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.2 L-tryptophan product inhibition at physiologic concentrations Homo sapiens
6.1.1.2 L-tryptophan product inhibition at physiologic concentrations Mus musculus
6.1.1.2 tryptamine a metabolic tryptophan analog that acts as a potent competitive inhibitor of TrpRS, overview Homo sapiens
6.1.1.2 tryptamine a metabolic tryptophan analog that acts as a potent competitive inhibitor of TrpRS, overview Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.2 Mg2+
-
 Mus musculus
6.1.1.2 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.2 ATP + L-tryptophan + tRNATrp Mus musculus
-
 AMP + diphosphate + L-tryptophanyl-tRNATrp
-
 ?
6.1.1.2 ATP + L-tryptophan + tRNATrp Homo sapiens
-
 AMP + diphosphate + L-tryptophanyl-tRNATrp
-
 ?
6.1.1.2 ATP + L-tryptophan + tRNATrp Mus musculus BALB/c
-
 AMP + diphosphate + L-tryptophanyl-tRNATrp
-
 ?
6.1.1.2 additional information Homo sapiens tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview ?
-
 ?
6.1.1.2 additional information Mus musculus tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview ?
-
 ?
6.1.1.2 additional information Mus musculus BALB/c tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.2 Homo sapiens
-
-
-
6.1.1.2 Mus musculus
-
 Balb/c mice
-
6.1.1.2 Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.2 brain
-
 Mus musculus
-
6.1.1.2 neuron
-
 Mus musculus
-
6.1.1.2 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.2 ATP + L-tryptophan + tRNATrp
-
 Mus musculus AMP + diphosphate + L-tryptophanyl-tRNATrp
-
 ?
6.1.1.2 ATP + L-tryptophan + tRNATrp
-
 Homo sapiens AMP + diphosphate + L-tryptophanyl-tRNATrp
-
 ?
6.1.1.2 ATP + L-tryptophan + tRNATrp
-
 Mus musculus BALB/c AMP + diphosphate + L-tryptophanyl-tRNATrp
-
 ?
6.1.1.2 additional information tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview Homo sapiens ?
-
 ?
6.1.1.2 additional information tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview Mus musculus ?
-
 ?
6.1.1.2 additional information tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview Mus musculus BALB/c ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.1.2 More TrpRS N-terminal peptide self-assembles in double-helical fibrils in vitro Mus musculus
6.1.1.2 More TrpRS N-terminal peptide self-assembles in double-helical fibrils in vitro Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
6.1.1.2 TrpRS
-
 Mus musculus
6.1.1.2 TrpRS
-
 Homo sapiens
6.1.1.2 Tryptophanyl-tRNA synthetase
-
 Mus musculus
6.1.1.2 Tryptophanyl-tRNA synthetase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.1.1.2 37
-
 assay at Mus musculus
6.1.1.2 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.1.1.2 7.5
-
 assay at Mus musculus
6.1.1.2 7.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.2 ATP
-
 Mus musculus
6.1.1.2 ATP
-
 Homo sapiens