Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Diwakar, L.; Ravindranath, V.
    Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS (2007), Neurochem. Int., 50, 418-426.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.1
-
 Mus musculus
4.4.1.1
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.1 L-beta-oxalyl amino-L-alanine inhibition only after long exposure Mus musculus
4.4.1.1 L-propargylglycine
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.1 cytosol
-
 Mus musculus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.1 Homo sapiens
-
-
-
4.4.1.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.1 brain acitvity only 1% of activity in liver Mus musculus
-
4.4.1.1 brain activity in human brain is 100fold higher than that observed in mouse brain Homo sapiens
-
4.4.1.1 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.1 L-cystathionine + H2O
-
 Mus musculus L-cysteine + 2-oxobutanoate + NH3
-
 ?
4.4.1.1 L-cystathionine + H2O
-
 Homo sapiens L-cysteine + 2-oxobutanoate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.1 cystathionine-gamma-lyase
-
 Mus musculus
4.4.1.1 cystathionine-gamma-lyase
-
 Homo sapiens
4.4.1.1 gamma-cystathionase
-
 Mus musculus
4.4.1.1 gamma-cystathionase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.1 pyridoxal 5'-phosphate
-
 Mus musculus