Literature summary extracted from

Min, J.; Kyung Kim, Y.; Cipriani, P.G.; Kang, M.; Khersonsky, S.M.; Walsh, D.P.; Lee, J.Y.; Niessen, S.; Yates, J.R.; Gunsalus, K.; Piano, F.; Chang, Y.T.
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling (2007), Nat. Chem. Biol., 3, 55-59.

Application

EC Number	Application	Comment	Organism
1.2.1.13	medicine	the results suggest that GAPDH is an active regulator in the phosphoinositide-mediated signaling pathway and a potential new target for insulin resistance treatment, diabetes, obesity and aging research	Oryctolagus cuniculus
1.2.1.13	medicine	the results suggest that GAPDH is an active regulator in the phosphoinositide-mediated signaling pathway and a potential new target for insulin resistance treatment, diabetes, obesity and aging research	Caenorhabditis elegans

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.2.1.13	6-Hydroxydopamine	-	Oryctolagus cuniculus
1.2.1.13	GAPDH segregator	GAPDS stimulates insulin signaling by segregating the tetrameric GAPDH into monomers, and thereby suppresses the intrinsic GAPDH activation of phosphoinositide's phosphatase activity	Caenorhabditis elegans
1.2.1.13	GAPDH segregator	GAPDH segregator, GAPDS, stimulates insulin signaling by segregating the tetrameric GAPDH into monomers, and thereby suppresses the intrinsic GAPDH activation of phosphoinositide's phosphatase activity	Oryctolagus cuniculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.2.1.13	Caenorhabditis elegans	-	-	-
1.2.1.13	Oryctolagus cuniculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.2.1.13	muscle	-	Oryctolagus cuniculus	-

Subunits

EC Number	Subunits	Comment	Organism
1.2.1.13	homotetramer	-	Oryctolagus cuniculus
1.2.1.13	tetramer	-	Caenorhabditis elegans

Synonyms

EC Number	Synonyms	Comment	Organism
1.2.1.13	GAPDH	-	Oryctolagus cuniculus
1.2.1.13	GAPDH	-	Caenorhabditis elegans
1.2.1.13	glyceraldehyde-3-phosphate dehydrogenase	-	Oryctolagus cuniculus
1.2.1.13	glyceraldehyde-3-phosphate dehydrogenase	-	Caenorhabditis elegans

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
1.2.1.13	0.008	-	-	Oryctolagus cuniculus	6-Hydroxydopamine
1.2.1.13	0.015	-	GAPDS inhibits the glycolytic enzymatic function of GAPDH	Oryctolagus cuniculus	GAPDH segregator

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Release 2023.1 (January 2023)