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Literature summary extracted from

  • Solaroli, N.; Zheng, X.; Johansson, M.; Balzarini, J.; Karlsson, A.
    Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (2007), Mol. Pharmacol., 72, 1593-1598.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.145 medicine mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential Drosophila melanogaster
2.7.1.145 medicine mitochondrial targeting of multisubstrate nucleoside kinase facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.145 expression in a thymidine kinase 1-deficient osteosarcoma cell line. Mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential Drosophila melanogaster
2.7.1.145 expression in osteosarcoma cell line Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.145 additional information engineering of multisubstrate nucleoside kinase targeted to the mitochondrial matrix and expression in thymidine kinase-1 deficient osteosarcoma cell line. Although the total deoxythymidine phosphorylation activity is similar in cells expressing multisubstrate nullceoside kinase in the nucleus or in the mitochondria, the cells expressing the enzyme in the mitochondria show higher sensitivity to the antiproliferative activity of pyrimidine nucleoside analogs, such as (E)-5-(2-bromovinyl)-2-deoxyuridine, 5-bromo-2-deoxyuridine, and 5-fluoro-2-deoxyuridine. Cells expressing the mitochondrial enzyme have an increased incorporation of [3H]dThd into DNA, due to a higher [3H]dTTP specific activity of the total dTTP pool in the cells in which the enzyme is targeted to the mitochondria Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.145 mitochondrion
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 Drosophila melanogaster 5739
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Organism

EC Number Organism UniProt Comment Textmining
2.7.1.145 Drosophila melanogaster
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.145 Dm-dNK
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 Drosophila melanogaster
2.7.1.145 multisubstrate deoxyribonucleoside kinase
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 Drosophila melanogaster