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Literature summary extracted from

  • Nagar, S.; Walther, S.; Blanchard, R.L.
    Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation (2006), Mol. Pharmacol., 69, 2084-2092.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 genetic polymorphisms in the SULT1A1 gene define three alleles, SULT1A1*1, *2, and *3, stable expression of the allozymes in MCF-7 cells, allele-specific antiestrogenic response to 4-hydroxytamoxifen, expression of His-tagged SULT1A1*1, *2, and *3 in Spodoptera frugiperda Sf9 cells via liposome transfection Homo sapiens

General Stability

EC Number General Stability Organism
2.8.2.1 the recombinant SULT1A1*2 protein has a shorter half-life than the recombinant SULT1A1*1 protein Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 additional information substrate inhibition of allozymes SULT1A1*1, *2 and *3 is observed for most substrates Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol Homo sapiens
-
 adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 additional information Homo sapiens SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and 4-nitrophenol ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.1 recombinant His-tagged SULT1A1*1, *2, and *3 from Spodoptera frugiperda Sf9 cells by metal affinity chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 2-methoxyestradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
2.8.2.1 additional information SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and 4-nitrophenol Homo sapiens ?
-
 ?
2.8.2.1 additional information substrate specifiicty of SULT1A1*1, *2, and *3, allozyme activities against catecholestrogens and dietary flavonoids, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 sulfotransferase 1A1
-
 Homo sapiens
2.8.2.1 SULT1A1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 6.5
-
 assay at Homo sapiens