Literature summary extracted from

Wan, L.; Cao, D.; Zeng, J.; Yan, R.; Pizzorno, G.
Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5-deoxy-5-fluorouridine in breast cancer cells (2006), Mol. Pharmacol., 69, 1389-1395.

Application

EC Number	Application	Comment	Organism
2.4.2.3	medicine	uridine phosphorylase plays an important role in the antineoplastic activity of 5-fluorouracil and in the anabolism of its oral prodrug, capecitabine, through the conversion of 5'-deoxy-5-fluorouridineinto 5-fluorouracil. TNF-alpha efficiently induces UPase gene expression through a NF-kappaB subunit p65-dependent pathway enhancing cell sensitivity to 5'-deoxy-5-fluorouridine. The elucidation of this regulation mechanism may aid in the clinical use of 5-fluorouracil-based chemotherapy	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.2.3	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.2.3	EMT6 cell	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.2.3	uridine + phosphate	-	Mus musculus	uracil + alpha-D-ribose 1-phosphate	-	?

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Release 2023.1 (January 2023)