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Literature summary extracted from

  • Zhao, A.; Gray, F.C.; MacNeill, S.A.
    ATP- and NAD+-dependent DNA ligases share an essential function in the halophilic archaeon Haloferax volcanii (2006), Mol. Microbiol., 59, 743-752.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Haloferax volcanii ATP-dependent DNA ligase LigA is non-essential for cell viability. Haloferax volcanii also encodes the NAD+-dependent DNA ligase LigN. As with LigA, LigN is also non-essential for cell viability. Simultaneous inactivation of both proteins is lethal, however, indicating that they share an essential function AMP + diphosphate + (deoxyribonucleotide)n+m
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6.5.1.2 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Haloferax volcanii NAD+-dependent DNA ligase LigN is non-essential for cell viability. Haloferax volcanii also encodes the ATP-dependent DNA ligase LigA. As with LigN, LigA is also non-essential for cell viability. Simultaneous inactivation of both proteins is lethal, however, indicating that they share an essential function AMP + diphosphate + (deoxyribonucleotide)n+m
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Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Haloferax volcanii
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-
-
6.5.1.2 Haloferax volcanii
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ATP-dependent DNA ligase LigA is non-essential for cell viability. Haloferax volcanii also encodes the NAD+-dependent DNA ligase LigN. As with LigA, LigN is also non-essential for cell viability. Simultaneous inactivation of both proteins is lethal, however, indicating that they share an essential function Haloferax volcanii AMP + diphosphate + (deoxyribonucleotide)n+m
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?
6.5.1.2 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m NAD+-dependent DNA ligase LigN is non-essential for cell viability. Haloferax volcanii also encodes the ATP-dependent DNA ligase LigA. As with LigN, LigA is also non-essential for cell viability. Simultaneous inactivation of both proteins is lethal, however, indicating that they share an essential function Haloferax volcanii AMP + diphosphate + (deoxyribonucleotide)n+m
-
?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 ATP-dependent DNA ligase
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Haloferax volcanii
6.5.1.1 LigA
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Haloferax volcanii
6.5.1.2 LigN
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Haloferax volcanii
6.5.1.2 NAD+-dependent DNA ligase
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Haloferax volcanii