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Literature summary extracted from

  • Chandler, R.J.; Aswani, V.; Tsai, M.S.; Falk, M.; Wehrli, N.; Stabler, S.; Allen, R.; Sedensky, M.; Kazazian, H.H.; Venditti, C.P.
    Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism (2006), Mol. Genet. Metab., 89, 64-73.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.1.99.1 medicine as model to study human methylmalonic aciduria, deletion of the mce gene results in a 80% decreased incorporation of propionate into macromolecules and induces an accumulation of methylmalonic acid Caenorhabditis elegans
5.4.99.2 medicine lentiviral delivery of enzyme gene into fibroblasts derived from a patient with mut0 class methylmalonic acidemia can partially restore propionate flux Caenorhabditis elegans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.99.1 in a RNAi vector in Escherichia coli Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
5.4.99.2 additional information enzyme depletion by RNA interference results in accumulation of methylmalonic acid. Enzyme deletion mutants display reduced propionate incorporation into macromolecules and produce increased amounts of methylmalonic acid in the culture medium. Lentiviral delivery of gene into fibroblasts derived from a patient with mut0 class methylmalonic acidemia can partially restore propionate flux Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.1.99.1 mitochondrion
-
 Caenorhabditis elegans 5739
-

Organism

EC Number Organism UniProt Comment Textmining
5.1.99.1 Caenorhabditis elegans
-
-
-
5.4.99.2 Caenorhabditis elegans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.99.1 (R)-methylmalonyl-CoA
-
 Caenorhabditis elegans (S)-methylmalonyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.1.99.1 MCE-1
-
 Caenorhabditis elegans
5.1.99.1 MCEE
-
 Caenorhabditis elegans
5.1.99.1 methylmalonyl-CoA 2-epimerase
-
 Caenorhabditis elegans
5.1.99.1 methylmalonyl-CoA epimerase
-
 Caenorhabditis elegans
5.4.99.2 mmcm-1
-
 Caenorhabditis elegans