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Literature summary extracted from

  • Goetzman, E.S.; He, M.; Nguyen, T.V.; Vockley, J
    Functional analysis of acyl-CoA dehydrogenase catalytic residue mutants using surface plasmon resonance and circular dichroism (2006), Mol. Genet. Metab., 87, 233-242.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.8.1 additional information development of a novel surface plasmon resonance assay to measure substrate binding Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.8.1 expressed in Escherichia coli XL1 Blue Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.3.8.1 E368G is unable to form a charge-transfer complex with substrate/product, does not efficiently compete with the wild-type enzyme for the physiological electron acceptor Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.1 isovaleryl-CoA dehydrogenase E254G inhibits wild-type SCAD Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.1 by chromatography and fractionation, to ca. 95% homogeneity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.1 butyryl-CoA + oxidized acceptor
-
 Homo sapiens crotonyl-CoA + reduced acceptor
-
 ?
1.3.8.1 crotonyl-CoA + reduced acceptor
-
 Homo sapiens butyryl-CoA + oxidized acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.1 SCAD
-
 Homo sapiens
1.3.8.1 short-chain acyl-CoA dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.1 FAD
-
 Homo sapiens