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Literature summary extracted from

  • Echchgadda, I.; Song, C.S.; Oh, T.; Ahmed, M.; De La Cruz, I.J.; Chatterjee, B.
    The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase (2007), Mol. Endocrinol., 21, 2099-2111.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.14 constitutive androstane receptor 3.5fold induction of SULT2A1 mRNAs in human cell lines of enterohepatic origin, such as Caco-2 intestinal cells and HepG2 hepatoma cells transfected with the CAR plasmid Homo sapiens
2.8.2.14 pregnane X receptor 1.7fold induction of SULT2A1 mRNAs in human cell lines of enterohepatic origin, such as Caco-2 intestinal cells and HepG2 hepatoma cells transfected with the PXR plasmid Homo sapiens
2.8.2.15 additional information the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor and constitutive androstane receptor, synergizing effects by HNF4alpha binding at a site near the promoter, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.15 gene SULT2A1, expression and regulation analysis, the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor, PXR, and constitutive androstane receptor, CAR, synergizing effects by HNF4alpha binding at a site near the promoter, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.8.2.15 additional information disruption of the DR4-type motif and the IR2-type motif prevents in vitro binding of nuclear receptors pregnane X receptor and constitutive androstane receptor to their specific binding sites, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.14 3'-phosphoadenylyl sulfate + glycolithocholate Homo sapiens the enzyme mediates catalytic conversion of hydroxysteroids, bile acids, and certain clinical drugs to water-soluble sulfated metabolites adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.15 additional information Homo sapiens the enzyme promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutics drugs, regulation of enzyme expression involving HNF4alpha, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.14 Homo sapiens Q06520
-
-
2.8.2.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.14 adrenal cortex
-
 Homo sapiens
-
2.8.2.14 Caco-2 cell
-
 Homo sapiens
-
2.8.2.14 Hep-G2 cell
-
 Homo sapiens
-
2.8.2.14 intestine
-
 Homo sapiens
-
2.8.2.14 liver
-
 Homo sapiens
-
2.8.2.15 Caco-2 cell
-
 Homo sapiens
-
2.8.2.15 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.14 3'-phosphoadenylyl sulfate + glycolithocholate
-
 Homo sapiens adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.14 3'-phosphoadenylyl sulfate + glycolithocholate the enzyme mediates catalytic conversion of hydroxysteroids, bile acids, and certain clinical drugs to water-soluble sulfated metabolites Homo sapiens adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
-
 ?
2.8.2.15 additional information the enzyme promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutics drugs, regulation of enzyme expression involving HNF4alpha, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.14 steroid-/bile acid-sulfotransferase
-
 Homo sapiens
2.8.2.14 SULT2A1
-
 Homo sapiens
2.8.2.15 steroid-/bile acid-sulfotransferase
-
 Homo sapiens
2.8.2.15 SULT2A1
-
 Homo sapiens