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Literature summary extracted from

  • Ajonuma, L.C.; Tsang, L.L.; Zhang, G.H.; Wong, C.H.; Lau, M.C.; Ho, L.S.; Rowlands, D.K.; Zhou, C.X.; Ng, C.P.; Chen, J.; Xu, P.H.; Zhu, J.X.; Chung, Y.W.; Chan, H.C.
    Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome (2005), Mol. Endocrinol., 19, 3038-3044.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.1.6 estrogen high amounts upregulate CFTR expression Rattus norvegicus

Application

EC Number Application Comment Organism
5.6.1.6 medicine CFTR is involved in the pathogenesis of ovarian hyperstimulation syndrome by reproduction treatments, upon ovarian hyperstimulation enhanced CFTR expression and channel activity Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
5.6.1.6 additional information CFTR mutants tm1Unc, no detectable ovarian hyperstimulation syndrome symptoms by ovarian hyperstimulation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.6 Antibody inhibits CFTR, alleviation of ovarian hyperstimulation syndrome symptoms Rattus norvegicus
5.6.1.6 progesterone supresses CFTR expression, alleviation of ovarian hyperstimulation syndrome symptoms Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.6 ovary
-
 Rattus norvegicus
-
5.6.1.6 uterus
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 CFTR
-
 Rattus norvegicus
5.6.1.6 cystic fibrosis transmembrane conductance regulator
-
 Rattus norvegicus